weak D type 4.2.2 (DAR1.2)

Structure

RHD(T201R,F223V,I342T)[744C>T,957G>A]

Key changes from standard allele

1025T>C (I342T)
602C>G (T201R)
667T>G (F223V)
744C>T
957 G>A

ISBT allele designation

RHD*09.01.02

Nucleotide changes relative to "standard RHD"

c.[602 C>G;667 T>G;744 C>T;957 G>A;1025 T>C]

Amino acid changes relative to standard protein

T201R, F223V, I342T

Haplotype (typical)

cDe

Allele cluster

weak D type 4 cluster

Descriptions

First full publication: 2000 Wagner FF et. al. Blood. 2000 Apr 15;95(8):2699-708. (submitted 1999-08-13)

Other relevant descriptions:
Informative on intron polymorphism KF712273 (submitted 2013-09-27, released 2013-11-05)

ISBT group

partial RHD

Phenotype characterization and grouping

Partial D; weak D type; weakened D expression

Serology

Antigen density given for "weak D type 4.2", not specified whether type 4.2.1. or type 4.2.2 Wagner FF et. al. Blood. 2000 Apr 15;95(8):2699-708.: allo-anti-D observed
754 â?? 1,542 antigens/cell (2 samples, 22 to 50 antibodies, 12 laboratories) Rhesus Index 0.33 â?? 0.78 (2 samples, 22 to 50 antibodies, 12 laboratories) weak D type 4.2 subtype not specified Flegel WA et. al. Transfus Clin Biol. 2002 Jan;9(1):33-42.

Observations

Brazil (general): 110 of 369 samples with atypical D expression Arnoni CP et. al. Transfusion. 2014 Apr;54(4):962-9. doi: 10.1111/trf.12557. Epub 2014 Feb 28.
Brazaville and Teke groups: Observed in 3 of 26 D positive samples Touinssi M et. al. Transfusion. 2009 Jul;49(7):1353-60.
French of African ancestry: 3 of 280 D pos donors, in addition 1 allele in heterozygous state; linked to RHCE*ceAR in 5 donors Kappler-Gratias S et. al. Blood Transfus. 2014 Jan;12 Suppl 1:s264-72. doi: 10.2450/2013.0270-12. Epub 2013
African ancestry (general): Wagner FF et. al. Blood. 2000 Apr 15;95(8):2699-708.
India (general): Fichou Y et. al. Transfusion. 2018 Feb 25. doi: 10.1111/trf.14552.

Related Alleles

DAR(T203A) [RHD(T201R,T203A,F223V,I342T)]
DAR2.1 [RHD(T201R,F223V,E233Q,I342T)[744C>T, 957G>A]]

Additional comments

ISBT name according to v4.1.In earlier versions of the ISBT nomenclature, RHD?09.01.02 was associated with the weak D type 4.2.3 structure.

Last update: 2018-05-23 (yyyy-MM-dd)