DVII

Structure

RHD(L110P)

Key changes from standard allele

329T>C (L110P)

ISBT allele designation

RHD*07.01
RHD*DVII.1

Nucleotide changes relative to "standard RHD"

c.329 T>C

Amino acid changes relative to standard protein

Leu to Pro at codon 110

L110P

Haplotype (typical)

CDe

Allele cluster

Eurasian D cluster

Descriptions

First full publication: 1995 Rouillac C et. al. Am J Hematol. 1995 May;49(1):87-8.

Other relevant descriptions:
intronic polymorphisms RHD(IVS5+219T>G) and RHD(IVS7+311G>C) JX181657 (submitted 2012-06-15, released 2012-09-01)
intronic polymorphisms RHD(IVS2+90T>G), RHD(IVS5+219T>G) and RHD(IVS7+311G>C) JX181658 (submitted 2012-06-15, released 2012-09-01)
Informative on intron polymorphisms KC515380 (submitted 2013-01-18, released 2013-04-30)

ISBT group

partial RHD

Phenotype characterization and grouping

Partial D; D category

Serology

Rhesus Index 0.48 Wagner FF et. al. Blood. 2000 Apr 15;95(8):2699-708.

Observations

Brazil (general): 6 of 369 samples with atypical D expression Arnoni CP et. al. Transfusion. 2014 Apr;54(4):962-9. doi: 10.1111/trf.12557. Epub 2014 Feb 28.
Linz region: 7 of 201 samples with weak expression of D Polin H et. al. Transfusion. 2007 Aug;47(8):1350-5.

Related Alleles

DVII type 2 [RHD(S103P,L110P)]
RHD(L110P)-CE(3-9)-D [RHD(L110P)-CE(3-9)-D]

Additional comments

Last update: 2018-02-19 (yyyy-MM-dd)