weak D type 146

Structure

RHD(E146D)

Key changes from standard allele

438G>C (E146D)

ISBT allele designation

No designation assigned

Nucleotide changes relative to "standard RHD"

c.438 G>C

Amino acid changes relative to standard protein

Glu to Asp at codon 146

E146D

Phenotypes observed

CcDe (major)

Haplotype (typical)

not reported

Allele cluster

Eurasian D cluster

Descriptions

First submission to GenBank: 2011 JN007073 (submitted 2011-05-19, released 2011-11-01)

First full publication: 2014 Ye SH et. al. Blood Transfus. 2014 Jul;12(3):396-404. doi: 10.2450/2013.0121-13. Epub 2013 Dec

ISBT group

Phenotype characterization and grouping

weakened D expression; weak D type

Serology

weakened D expression JN007073
positive in IAT only, with 12 monoclonals no epitope loss detected. Ye SH et. al. Blood Transfus. 2014 Jul;12(3):396-404. doi: 10.2450/2013.0121-13. Epub 2013 Dec

Observations

Xian: 1 of 2493 samples D negative in saline Ye SH et. al. Blood Transfus. 2014 Jul;12(3):396-404. doi: 10.2450/2013.0121-13. Epub 2013 Dec

Additional comments

Last update: 2018-05-23 (yyyy-MM-dd)