DVI type 3



Key changes from standard allele

Hybrid RHCE(3-6)

ISBT allele designation


Nucleotide changes relative to "standard RHD"

c.[361 T>A;380 T>C;383 A>G;455 A>C;505 A>C;509 T>G;514 A>T;544 T>A;577 G>A;594 A>T;602 C>G;667 T>G;697 G>C;712 G>A;733 G>C;744 C>T;787 G>A;800 A>T;916 G>A;932 A>G]

Amino acid changes relative to standard protein

L121M, V127A, D128G, N152T, M169L, M170R, I172F, S182T, E193K, K198N, T201R, F223V, E233Q, V238M, V245L, G263R, K267M, V306I, Y311C

Phenotypes observed

CcDe (major)
CDe (to confirm)
cDe (to confirm)
CcDEe (to confirm)

Haplotype (typical)


Allele cluster

Eurasian D cluster


First submission to GenBank: 1998 Z97026 (submitted 1997-06-25, released 1998-01-10)

First full publication: 1998 Wagner FF et. al. Blood. 1998 Mar 15;91(6):2157-68.

ISBT group

partial RHD

Phenotype characterization and grouping

Partial D; D category; BARC positive


Lacks epitopes 1,2,4,5,6,8 (9 epitope model); BARC positive Wagner FF et. al. Blood. 1998 Mar 15;91(6):2157-68.


China (general): Most frequent DVI phenotype Yan L et. al. Transfusion. 2007 Mar;47(3):471-7.
China (general): 36 of 44 partial D samples Ye L et. al. Transfusion. 2012 Feb;52(2):241-6.
Xian: 31 of 2493 samples D negative in saline Ye SH et. al. Blood Transfus. 2014 Jul;12(3):396-404. doi: 10.2450/2013.0121-13. Epub 2013 Dec
China (general): 3 of 32 samples with D variant phenotype He J et. al. Transfusion. 2015 Jan;55(1):137-43. doi: 10.1111/trf.12797. Epub 2014 Jul 29.
South-Western Germany: Rare allele: 2 of 15 DVI samples Wagner FF et. al. Blood. 1998 Mar 15;91(6):2157-68.
India (general): Fichou Y et. al. Transfusion. 2018 Feb 25. doi: 10.1111/trf.14552.

Related Alleles

DVI type 3.2 [RHD-RHCE(3-6)-RHD(A399T)]
RHCE(1-9)-RHD [RHCE(1-9)-RHD]
RHD-RHCE(2-10) [RHD-RHCE(2-10)]
RHD(L110P)-CE(3-9)-D [RHD(L110P)-CE(3-9)-D]
RHD(S68T)-RHCe(3-9)-RHD [RHD(S68T)-RHCE(3-9)-RHD]
RHD-RHCe(2-9)-RHD [RHD-RHCe(2-9)-RHD]
RHD-RHCe(2-9)-RHD1 [RHD-RHCE(3-9)-RHD]
RHD-RHCe(2-9)-RHD2 [RHD-RHCE(3-9)-RHD]

Additional comments

Last update: 2018-05-23 (yyyy-MM-dd)