DVI type 3

Structure

RHD-RHCE(3-6)-RHD

Key changes from standard allele

Hybrid RHCE(3-6)

ISBT allele designation

RHD*06.03
RHD*DVI.3

Nucleotide changes relative to "standard RHD"

c.[361 T>A;380 T>C;383 A>G;455 A>C;505 A>C;509 T>G;514 A>T;544 T>A;577 G>A;594 A>T;602 C>G;667 T>G;697 G>C;712 G>A;733 G>C;744 C>T;787 G>A;800 A>T;916 G>A;932 A>G]

Amino acid changes relative to standard protein

L121M, V127A, D128G, N152T, M169L, M170R, I172F, S182T, E193K, K198N, T201R, F223V, E233Q, V238M, V245L, G263R, K267M, V306I, Y311C

Phenotypes observed

CcDe (major)
CDe (to confirm)
cDe (to confirm)
CcDEe (to confirm)

Haplotype (typical)

CDe

Allele cluster

Eurasian D cluster

Descriptions

First submission to GenBank: 1998 Z97026 (submitted 1997-06-25, released 1998-01-10)

First full publication: 1998 Wagner FF et. al. Blood. 1998 Mar 15;91(6):2157-68.

ISBT group

partial RHD

Phenotype characterization and grouping

Partial D; D category; BARC positive

Serology

Lacks epitopes 1,2,4,5,6,8 (9 epitope model); BARC positive Wagner FF et. al. Blood. 1998 Mar 15;91(6):2157-68.

Observations

China (general): Most frequent DVI phenotype Yan L et. al. Transfusion. 2007 Mar;47(3):471-7.
China (general): 36 of 44 partial D samples Ye L et. al. Transfusion. 2012 Feb;52(2):241-6.
Xian: 31 of 2493 samples D negative in saline Ye SH et. al. Blood Transfus. 2014 Jul;12(3):396-404. doi: 10.2450/2013.0121-13. Epub 2013 Dec
South-Western Germany: Rare allele: 2 of 15 DVI samples Wagner FF et. al. Blood. 1998 Mar 15;91(6):2157-68.

Additional comments

Last update: 2018-02-19 (yyyy-MM-dd)