DVI type 4

Structure

RHD-RHCE(3-5)-RHD

Key changes from standard allele

Hybrid RHCE(3-5)

ISBT allele designation

RHD*06.04
RHD*DVI.4

Nucleotide changes relative to "standard RHD"

c.[361 T>A;380 T>C;383 A>G;455 A>C;505 A>C;509 T>G;514 A>T;544 T>A;577 G>A;594 A>T;602 C>G;667 T>G;697 G>C;712 G>A;733 G>C;744 C>T;787 G>A;800 A>T]

Amino acid changes relative to standard protein

L121M, V127A, D128G, N152T, M169L, M170R, I172F, S182T, E193K, K198N, T201R, F223V, E233Q, V238M, V245L, G263R, K267M

Haplotype (typical)

CDe

Allele cluster

Eurasian D cluster

Descriptions

First submission to GenBank: 2000 AF312679 (submitted 2000-10-09, released 2000-12-18)

First full publication: 2006 Esteban R et. al. Transfusion. 2006 Apr;46(4):616-23.

ISBT group

partial RHD

Phenotype characterization and grouping

Partial D; D category

Serology

DVI phenotype Esteban R et. al. Transfusion. 2006 Apr;46(4):616-23.
Detected among DEL phenotypes Li Q et. al. Vox Sang. 2009 Aug;97(2):139-46. Epub 2009 Mar 30.

Observations

Spain (general): Most frequent DVI allele in Spain Esteban R et. al. Transfusion. 2006 Apr;46(4):616-23.
China (general): Li Q et. al. Vox Sang. 2009 Aug;97(2):139-46. Epub 2009 Mar 30.

Additional comments

The RHD-RHCE(3-5)-RHD structure has also been reported for DHMii, which was described 1996 but never fully characterized or detected again.

Last update: 2012-03-27 (yyyy-MM-dd)