DVI type 4

Structure

RHD-RHCE(3-5)-RHD

Key changes from standard allele

Hybrid RHCE(3-5)

ISBT allele designation

RHD*06.04
RHD*DVI.4

Nucleotide changes relative to "standard RHD"

c.[361 T>A;380 T>C;383 A>G;455 A>C;505 A>C;509 T>G;514 A>T;544 T>A;577 G>A;594 A>T;602 C>G;667 T>G;697 G>C;712 G>A;733 G>C;744 C>T;787 G>A;800 A>T]

Amino acid changes relative to standard protein

L121M, V127A, D128G, N152T, M169L, M170R, I172F, S182T, E193K, K198N, T201R, F223V, E233Q, V238M, V245L, G263R, K267M

ISBT group

partial RHD

Phenotype characterization and grouping

Partial D; D category

Haplotype (typical)

CDe

Allele cluster

Eurasian D cluster

Descriptions

First submission to GenBank: 2000 AF312679 (submitted 2000-10-09, released 2000-12-18)

First full publication: 2006 Esteban R et. al. Transfusion. 2006 Apr;46(4):616-23.

Serology

DVI phenotype Esteban R et. al. Transfusion. 2006 Apr;46(4):616-23.
Detected among DEL phenotypes Li Q et. al. Vox Sang. 2009 Aug;97(2):139-46. Epub 2009 Mar 30.

Observations

Spain (general): Most frequent DVI allele in Spain Esteban R et. al. Transfusion. 2006 Apr;46(4):616-23.
China (general): Li Q et. al. Vox Sang. 2009 Aug;97(2):139-46. Epub 2009 Mar 30.

Related Alleles

DVI type 3 [RHD-RHCE(3-6)-RHD]
DVI type 3.2 [RHD-RHCE(3-6)-RHD(A399T)]
RHCE(1-9)-RHD [RHCE(1-9)-RHD]
RHD-RHCE(2-10) [RHD-RHCE(2-10)]
RHD-RHCe(2-7)-RHD [RHD-RHCE(3-7)-RHD]
RHD(L110P)-CE(3-9)-D [RHD(L110P)-CE(3-9)-D]
RHD(S68T)-RHCe(3-9)-RHD [RHD(S68T)-RHCE(3-9)-RHD]
RHD-RHCe(2-9)-RHD [RHD-RHCe(2-9)-RHD]
RHD-RHCe(2-9)-RHD1 [RHD-RHCE(3-9)-RHD]
RHD-RHCe(2-9)-RHD2 [RHD-RHCE(3-9)-RHD]

Additional comments

The RHD-RHCE(3-5)-RHD structure has also been reported for DHMii, which was described 1996 but never fully characterized or detected again.

Last update: 2012-03-27 (yyyy-MM-dd)