DV type 8



Key changes from standard allele

Hybrid RHCE(5:667-5:744)

ISBT allele designation


Nucleotide changes relative to "standard RHD"

c.[667 T>G;697 G>C;712 G>A;733 G>C;744 C>T]

Amino acid changes relative to standard protein

F223V, E233Q, V238M, V245L

Haplotype (typical)


Allele cluster

Eurasian D cluster


First submission to GenBank: 1998 AB012660 (submitted 1998-03-30, released 1998-09-08)

First full publication: 1999 Omi T et. al. Biochem Biophys Res Commun. 1999 Jan 27;254(3):786-94.

Other relevant descriptions:
Designated DVa (TT) AB018968 (submitted 1998-10-20, released 1999-07-06)

ISBT group

partial RHD

Phenotype characterization and grouping

Partial D; D category


No data


No data

Additional comments

The notation used in the RhesusBase is an extension of the numbering introduced by Avent & Reid 2000 and supported by the ISBT. The allele was first described 1998 in a GenBank entry belonging to the same manuscript as Wagner et al. 2001. This allele is listed as DVa 2 in the Human Blood Group mutation datatabase (accessed 2012-Jan-22), .
Note: The silent substitution at position 744 is present in both sequences but not mentioned in the provisional ISBT nomenclature.

Last update: 2012-03-25 (yyyy-MM-dd)