DV type 8

Structure

RHD-RHCE(5:667-5:744)-RHD

Key changes from standard allele

Hybrid RHCE(5:667-5:744)

ISBT allele designation

RHD*05.08
RHD*DV.8

Nucleotide changes relative to "standard RHD"

c.[667 T>G;697 G>C;712 G>A;733 G>C;744 C>T]

Amino acid changes relative to standard protein

F223V, E233Q, V238M, V245L

Haplotype (typical)

CDe

Allele cluster

Eurasian D cluster

Descriptions

First submission to GenBank: 1998 AB012660 (submitted 1998-03-30, released 1998-09-08)

First full publication: 1999 Omi T et. al. Biochem Biophys Res Commun. 1999 Jan 27;254(3):786-94.

Other relevant descriptions:
Designated DVa (TT) AB018968 (submitted 1998-10-20, released 1999-07-06)

ISBT group

partial RHD

Phenotype characterization and grouping

Partial D; D category

Serology

No data

Observations

No data

Related Alleles

DVI type 2 [RHD-RHCE(4-6)-RHD]
RHD(A137V,N152T)-CE(4-6)-D(7-10) [RHD(A137V,N152T)-CE(4-6)-D(7-10)]
DVI type 1 [RHD-RHcE(4-5)-RHD]
DBS-1 [RHD-RHcE(5:667-5:800)-RHD]
DBT-1 [RHD-RHCe(5-7)-RHD]
DBT-2 [RHD-RHCe(5-9)-RHD]
DBU [RHD-cE(5-7;226P)-D]
DVI type 4 [RHD-RHCE(3-5)-RHD]
DV type 2 [RHD-RHCE(5)-RHD]
RHD(T201R)-CE(5)-D(I342T) [RHD(T201R)-CE(5)-D(I342T)]
DV type 7 [RHD-RHCE(5:667-5:787)-RHD]
DVI type 3 [RHD-RHCE(3-6)-RHD]
DVI type 3.2 [RHD-RHCE(3-6)-RHD(A399T)]
DV type 10 [RHD-RHCE(5-6)-RHD]
RHCE(1-9)-RHD [RHCE(1-9)-RHD]
RHD-RHCE(2-10) [RHD-RHCE(2-10)]
RHD-RHCe(2-7)-RHD [RHD-RHCE(3-7)-RHD]
RHD(L110P)-CE(3-9)-D [RHD(L110P)-CE(3-9)-D]
RHD(S68T)-RHCe(3-9)-RHD [RHD(S68T)-RHCE(3-9)-RHD]
RHD-RHCe(2-9)-RHD [RHD-RHCe(2-9)-RHD]
RHD-RHCe(2-9)-RHD1 [RHD-RHCE(3-9)-RHD]
RHD-RHCe(2-9)-RHD2 [RHD-RHCE(3-9)-RHD]
RHD-RHCE(4-7)-RHD [RHD-RHCE(4-7)-RHD]
RHD-RHCE(4-7)-RHD1 [RHD-RHCE(4-7)-RHD]
RHD-RHCE(4-7)-RHD2 [RHD-RHCE(4-7)-RHD]
RHD-RHCE(4-8)-RHD [RHD-RHCE(4-7)-RHD]
RHD-RHCE(4-9)-RHD [RHD-RHCE(4-9)-RHD]
RHD-cE(5-6)-D [RHD-cE(5-6)-D]
RHD-RHCE(2-5)-RHD [RHD-RHCE(2-5)-RHD]

Additional comments

The notation used in the RhesusBase is an extension of the numbering introduced by Avent & Reid 2000 and supported by the ISBT. The allele was first described 1998 in a GenBank entry belonging to the same manuscript as Wagner et al. 2001. This allele is listed as DVa 2 in the Human Blood Group mutation datatabase (accessed 2012-Jan-22), .
Note: The silent substitution at position 744 is present in both sequences but not mentioned in the provisional ISBT nomenclature.

Last update: 2012-03-25 (yyyy-MM-dd)