DIIIb (Caucasian)

Structure

RHD-RHCE(2)-RHD

Caution: This structure most likely does not exist

Key changes from standard allele

Hybrid RHCE(2)

ISBT allele designation

RHD*03.02
RHD*DIIIb

Nucleotide changes relative to "standard RHD"

c.[150 T>C;178 A>C;201 G>A;203 G>A;307 T>C]

Amino acid changes relative to standard protein

, I60L, S68N, S103P

Haplotype (typical)

cDE

Allele cluster

Eurasian D cluster

Descriptions

First full publication: 1995 Rouillac C et. al. Blood. 1995 May 15;85(10):2937-44.

ISBT group

partial RHD

Phenotype characterization and grouping

weakened D expression; Partial D

Serology

No data

Observations

No data

Related Alleles

DHAR [RHCE-RHD(5)-RHCE]
DIII type 7 [RHD-RHCE(2)-RHD(A137V,N152T,T201R,F223V)]
DIIIa-ceS(1-2)-D(3)-ceS(4-7)-D [DIIIa-ceS(1-2)-D(3)-ceS(4-7)-D]
RHD-ceAG.05(2)-D [RHD-RHCE(2)-RHD(A85G)]
DKK [RHD-RHCE(2-3)-RHD]
RHCE(1-3)-RHD(4-10) [RHD(Hybrid RHCE(1-3))]
RHCE(1-9)-RHD [RHCE(1-9)-RHD]
RHD-RHCE(2-10) [RHD-RHCE(2-10)]
RHD-RHCE(2-5)-RHD [RHD-RHCE(2-5)-RHD]

Additional comments

This allele in unlikely to exist. Samples assigned to this allele most likely represented This structure is found in some European samples. In 1995 it was suggested that it was underlying the DIIIb phenotype, and samples with this structure are likely to have been used as "DIIIb" controls. In 2011, it was shown that the "original" DIIIb samples had a different structure known as DIII type 7, and the name weak D type 74 was proposed for this structure although there was no satisfying serologic characterization as weak D and the name weak D type 74 was already in use for RHD(S68T). In order to reduce the confusion caused by this switch of meaning of "DIIIb allele", the designation DIIIb was retained for this allele. Note: this allele is usually grouped with partial D, although it lacks only antigen G.

Last update: 2017-01-28 (yyyy-MM-dd)