RHD(Y34C)

Structure

RHD(Y34C)

Key changes from standard allele

101A>G (Y34C)

ISBT allele designation

No designation assigned

Nucleotide changes relative to "standard RHD"

c.101 A>G

Amino acid changes relative to standard protein

Tyr to Cys at codon 34

Y34C

Phenotypes observed

cDEe (major)

Haplotype (typical)

not reported

Allele cluster

Eurasian D cluster

Descriptions

First submission to GenBank: 2011 JF830785 (submitted 2011-04-22, released 2011-10-03)

Other relevant descriptions:
JQ405076 (submitted 2012-01-09, released 2012-04-21)
KF142380 (submitted 2013-05-22, released 2013-09-18)
KP718116 (submitted 2015-01-28, released 2015-07-25)

ISBT group

Phenotype characterization and grouping

weakened D expression

Serology

weak D KF142380
weak D JF830785
weak D variant KP718116
positive in IAT only, with 12 monoclonals no epitope loss detected. Ye SH et. al. Blood Transfus. 2014 Jul;12(3):396-404. doi: 10.2450/2013.0121-13. Epub 2013 Dec

Observations

China (general): KF142380
China (general): JF830785
China (general): KP718116
China (general): 1 of 32 samples with weak D phenotype He J et. al. Transfusion. 2015 Jan;55(1):137-43. doi: 10.1111/trf.12797. Epub 2014 Jul 29.
France (general): JQ405076
Xian: 1 of 2493 samples D negative in saline Ye SH et. al. Blood Transfus. 2014 Jul;12(3):396-404. doi: 10.2450/2013.0121-13. Epub 2013 Dec

Additional comments

Last update: 2018-05-23 (yyyy-MM-dd)