weak D type 1.2

Structure

RHD(V238M,V270G)

Key changes from standard allele

712G>A (V238M)
809T>G (V270G)

ISBT allele designation

RHD*01w.1.2
RHD*weak D type 1.2

Nucleotide changes relative to "standard RHD"

712 G>A, 809 T>G

Amino acid changes relative to standard protein

V238M, V270G

Haplotype (typical)

CDe

Allele cluster

Eurasian D cluster

Descriptions

First submission to GenBank: 2014 KJ145902 (submitted 2014-01-13, released 2014-02-18)

First full publication: 2014 Garcia F et. al. Transfusion. 2015 Feb;55(2):427-9.

Other relevant descriptions:
KT935443 (submitted 2015-10-16, released 2016-09-04)

ISBT group

weak D

Phenotype characterization and grouping

weak D type; weakened D expression

Serology

Weak D Garcia F et. al. Transfusion. 2015 Feb;55(2):427-9.

Observations

USA (general): KT935443
France (general): Not detected among 256 weak D type 1-like samples Raud L et. al. Transfus Med. 2017 Nov 22. doi: 10.1111/tme.12485.

Additional comments

Haplotype DCe or Dce

Last update: 2017-12-05 (yyyy-MM-dd)