DAR1 (weak D type 4.2.0)

Structure

RHD(T201R,F223V,I342T)

Key changes from standard allele

1025T>C (I342T)
602C>G (T201R)
667T>G (F223V)

ISBT allele designation

RHD*09.01.00
RHD*DAR1.00

Nucleotide changes relative to "standard RHD"

c.[602 C>G;667 T>G;1025 T>C]

Amino acid changes relative to standard protein

T201R, F223V, I342T

ISBT group

partial RHD

Phenotype characterization and grouping

Partial D; weak D type; weakened D expression

Haplotype (typical)

cDe

Allele cluster

weak D type 4 cluster

Descriptions

First mention in abstract form: 1998 Hemker M & et al. Vox Sang 74:1331, 1998

First full publication: 1999 Hemker MB et. al. Blood. 1999 Dec 15;94(12):4337-42. (submitted 1999-06-01, released 1999-12-10)

Serology

May produce anti-D, but allo-anti-D immunization seems rare Hemker MB et. al. Blood. 1999 Dec 15;94(12):4337-42.
754 â?? 1,542 antigens/cell (2 samples, 22 to 50 antibodies, 12 laboratories) Rhesus Index 0.33 â?? 0.78 (2 samples, 22 to 50 antibodies, 12 laboratories) weak D type 4.2 subtype not specified Flegel WA et. al. Transfus Clin Biol. 2002 Jan;9(1):33-42.

Observations

South Africa (general): 14 of 326 donors Hemker MB et. al. Blood. 1999 Dec 15;94(12):4337-42. Frequency 1:34
African ancestry (general): Hemker MB et. al. Blood. 1999 Dec 15;94(12):4337-42.
African American: SWiTCH trial. Subtype not specified Chou ST et. al. Blood Adv. 2017 Aug 3;1(18):1414-1422. doi: 10.1182/bloodadvances.2017007898. Frequency 1:0,009
Brazaville and Teke groups: Observed in 1 of 140 samples presumed D negative Touinssi M et. al. Transfusion. 2009 Jul;49(7):1353-60.

Related Alleles

Ccdes-1 [RHD(L62F,A137V,N152T)-RHCE(4-7)-RHD(G336C)]
Ccdes-2 [RHD-RHCE(4-7)-RHD(G336C)]
DIIIa-ceS(1-2)-D(3)-ceS(4-7)-D [DIIIa-ceS(1-2)-D(3)-ceS(4-7)-D]
DAR(CE2:V50V-S68N) [RHD(150T>C,178A>C,201G>A,203G>A,602C>G,667T>G,957G>A,1025T>C)]
DAR(T203A) [RHD(T201R,T203A,F223V,I342T)]
DAR-E [RHD(T201R,F223V,E233Q,I342T)[957G>A]]
DAR2.1 [RHD(T201R,F223V,E233Q,I342T)[744C>T, 957G>A]]
RHD(T201R)-CE(5)-D(I342T) [RHD(T201R)-CE(5)-D(I342T)]
weak D type 4.2.1 (DAR1.1) [RHD(T201R,F223V,,I342T)[957G>A]]
weak D type 4.2.2 (DAR1.2) [RHD(T201R,F223V,I342T)[744C>T,957G>A]]
weak D type 4.2.3 (DAR1.3) [RHD(T201R,F223V,I342T)[744C]]
RHCE(1-9)-RHD [RHCE(1-9)-RHD]
RHD-RHCE(2-10) [RHD-RHCE(2-10)]
RHD-RHCe(2-7)-RHD [RHD-RHCE(3-7)-RHD]
RHD(L110P)-CE(3-9)-D [RHD(L110P)-CE(3-9)-D]
RHD(S68T)-RHCe(3-9)-RHD [RHD(S68T)-RHCE(3-9)-RHD]
RHD-RHCe(2-9)-RHD [RHD-RHCe(2-9)-RHD]
RHD-RHCe(2-9)-RHD1 [RHD-RHCE(3-9)-RHD]
RHD-RHCe(2-9)-RHD2 [RHD-RHCE(3-9)-RHD]
RHD-RHCE(4-7)-RHD [RHD-RHCE(4-7)-RHD]
RHD-RHCE(4-7)-RHD1 [RHD-RHCE(4-7)-RHD]
RHD-RHCE(4-7)-RHD2 [RHD-RHCE(4-7)-RHD]
RHD-RHCE(4-8)-RHD [RHD-RHCE(4-7)-RHD]
RHD-RHCE(4-9)-RHD [RHD-RHCE(4-9)-RHD]

Additional comments

This allele seems to have been forgotten by the ISBT, the name has been associated with the weak D type 4.2.1 structure. However, in addition to the first description there is at least one independent observation.

Last update: 2018-02-18 (yyyy-MM-dd)