DNB

Structure

RHD(G355S)

Key changes from standard allele

1063G>A (G355S)

ISBT allele designation

RHD*25
RHD*DNB

Nucleotide changes relative to "standard RHD"

c.1063 G>A

Amino acid changes relative to standard protein

Gly to Ser at codon 355

G355S

ISBT group

partial RHD

Phenotype characterization and grouping

Partial D

Haplotype (typical)

CDe

Allele cluster

Eurasian D cluster

Descriptions

First submission to GenBank: 2006 AJ417868 (submitted 2001-10-23, released 2006-11-14)

First full publication: 2002 Wagner FF et. al. Blood. 2002 Sep 15;100(6):2253-6.

Serology

Rhesus index 0.02. Five anti-D immunization events Wagner FF et. al. Blood. 2002 Sep 15;100(6):2253-6.: anti-D 1:128

Observations

South-Western Germany: Wagner FF et. al. Blood. 2002 Sep 15;100(6):2253-6. Frequency 1:1.295
Switzerland (general): Frequency in Switzerland 1:220 â?? 1:395 Wagner FF et. al. Blood. 2002 Sep 15;100(6):2253-6. Frequency 1:292
Brazil (general): 1 of 369 samples with atypical D expression Arnoni CP et. al. Transfusion. 2014 Apr;54(4):962-9. doi: 10.1111/trf.12557. Epub 2014 Feb 28.

Related Alleles

weak D type 4.5 [RHD(T201R,F223V,G355S)]
RHD-RHCE(2)-RHD(F355S) [RHD-RHCE(2)-RHD(F355S)]

Additional comments

Last update: 2018-02-19 (yyyy-MM-dd)