cDE

DesignationISBT nameClusterPhenotypeMechanismAlterationsFirst mentionDefinitive publication
DBS-1RHD*13.01
RHD*DBS1
Eurasian D clusterPartial Dhybrid alleleHybrid RHcE[226P](5:667-5:800)
20012001
DBS-2RHD*13.02
RHD*DBS2
Eurasian D clusterPartial Dhybrid alleleHybrid RHcE[226P](5:667-5:697)
20092012
DBURHD*41
RHD*DBU
RHD*01EL.23
Eurasian D clusterDEL
Partial D
hybrid alleleHybrid RHcE[226P](5-7)
20082009
DCS-1RHD*16.01
RHD*DCS1
Eurasian D clusterPartial Dhybrid allele667T>G (F223V)
676G>C (A226P)
19992008
DCS-2RHD*16.02
RHD*DCS2
Eurasian D clusterPartial DSingle missense mutation676G>C (A226P)
20082008
DHMiRHD*19
RHD*DHMi
Eurasian D clusterPartial DSingle missense mutation848C>T (T283I)
1996
DHMiiEurasian D clusterPartial Dhybrid allele1996
DIMRHD*34
RHD*DIM
Eurasian D clusterPartial D
weakened D expression
Single missense mutation854G>A (C285Y)
20002000
DIV type 5RHD*04.05
RHD*DIV.5
Eurasian D clusterPartial D
D category
hybrid alleleHybrid RHCE(7-9)
20002000
DKKRHD*45
RHD*DKK
Eurasian D clusterPartial Dhybrid alleleHybrid RHCE(2-3)
20002001
DLXRHD*46
RHD*DLX
Eurasian D clusterPartial DComplex changes667T>G (F223V)
Hybrid RHCE(5:712-6)
20122012
DNAKRHD*24
RHD*DNAK
Eurasian D clusterPartial DSingle missense mutation1070G>A (G357D)
2005
DNURHD*26
RHD*DNU
Eurasian D clusterPartial DSingle missense mutation1057G>A (G353R)
19971997
DVI type 1RHD*06.01
RHD*DVI.1
Eurasian D clusterD category
Partial D
hybrid alleleHybrid RHcE[226P](4-5)
19971997
RHCE(1-3)-RHD(4-10)RHD*01N.43Eurasian D clusterD negativehybrid alleleHybrid RHCE(1-3)
20042009
RHCE(1-9)-RHDRHD*01N.02Eurasian D clusterD negativehybrid alleleHybrid RHCE(1-9)
20012001
RHD(IVS1+1G>T)RHD*01EL.31
RHD*DEL31
Eurasian D clusterDELSplice site mutationIVS1+1G>T
20142014
weak D type 95RHD* 01W.95
RHD*weak D type 95
Eurasian D clusterweak D type
weakened D expression
Single missense mutation730G>C (A244P)
20132013
RHD(D404H)RHD*01EL.29
RHD*DEL29
Eurasian D clusterDELSingle missense mutation1210G>C (D404H)
2012
RHD(IVS3+2T>A)RHD*01EL.09
RHD*DEL9
Eurasian D clusterD negativeSplice site mutationIVS3+2T>A
20082009
RHD(IVS4-2A>C)RHD*54Eurasian D clusterPartial DSplice site mutationIVS4-2A>C
20142014
RHD(IVS8+6T>C)Eurasian D clusterweakened D expressionSplice site mutation2012
RHD(L153P)RHD*01EL.12
RHD*DEL12
Eurasian D clusterDELSingle missense mutation458T>C (L153P)
20042009
weak D type 83RHD* 01W.83
RHD*weak D type 83
Eurasian D clusterweakened D expressionSingle missense mutation1238T>G (L413W)
2012
RHD(M1T)Eurasian D clusterLoss of start codon2T>C (M1T)
20152015
RHD(S103P)RHD*39Eurasian D clusterPartial DSingle missense mutation307T>C (S103P)
19961996
weak D type 98RHD* 01W.98
RHD*weak D type 98
Eurasian D clusterweak D type
weakened D expression
Single missense mutation751A>C (T251P)
20132013
weak D type 2.2RHD*01W.2.2
RHD*weak D type 2.2
Eurasian D clusterweak D type
weakened D expression
Multiple missense mutations1154G>C (G385A)
916G>A (V306I)
932A>G (Y311C)
20142014
RHD(W16R)RHD*01EL.43
RHD*DEL43
Eurasian D clusterDELSingle missense mutation46T>C (W16R)
2012
weak D type 106RHD* 01W.106
RHD*weak D type 106
Eurasian D clusterweak D type
weakened D expression
Single missense mutation220T>G (W74G)
20152015
RHD(Y343X)RHD*01N.40Eurasian D clusterD negativeNonsense mutation1029C>A (Y343X)
20122013
RHD(Y401X)RHD*01N.22
RHD*DEL17
RHD*01EL.17
Eurasian D clusterD negativeNonsense mutation1203T>A (Y401X)
20042005
RHD-RHCE(4-7)-RHDRHD*01N.07Eurasian D clusterD negativehybrid alleleHybrid RHCE(4-7)
19961996
RHD-RHCE(4-7)-RHD1RHD*01N.07Eurasian D clusterD negativehybrid alleleHybrid RHCE(4-7)
RHD-RHCE(4-7)-RHD2RHD*01N.07Eurasian D clusterD negativehybrid alleleHybrid RHCE(4-7)
RHD-RHCE(7)-RHDRHD*58Eurasian D clusterPartial D
D category
hybrid alleleHybrid RHCE(7)
2012
weak D type 10RHD*01W.10
RHD*weak D type 10
Eurasian D clusterweak D type
weakened D expression
Single missense mutation1177T>C (W393R)
19991999
weak D type 14RHD*01W.14
RHD*weak D type 14
Eurasian D clusterweak D type
weakened D expression
Multiple missense mutations544T>A (S182T)
594A>T (K198N)
602C>G (T201R)
19991999
weak D type 15RHD*15
RHD*weak partial 15
Eurasian D clusterweak D type
weakened D expression
Partial D
Single missense mutation845G>A (G282D)
19991999
weak D type 16RHD*01W.16
RHD*weak D type 16
Eurasian D clusterweak D type
weakened D expression
Single missense mutation658T>C (W220R)
19991999
weak D type 2RHD*01W.2
RHD*weak D type 2
Eurasian D clusterweak D type
weakened D expression
Missense (splice site affected)1154G>C (G385A)
19991999
weak D type 2.1RHD*01W.2.1
RHD*weak D type 2.1
Eurasian D clusterweak D type
weakened D expression
Multiple missense mutations1154G>C (G385A)
301T>A (F101I)
2009
weak D type 20RHD*01W.20
RHD*weak D type 20
Eurasian D clusterweak D typeSingle missense mutation1250T>C (F417S)
20002006
weak D type 48RHD*01W.48
RHD*weak D type 48
Eurasian D clusterweak D type
weakened D expression
Single missense mutation182G>T (G61V)
2005
weak D type 5RHD*01W.5
RHD*weak D type 5
Eurasian D clusterweak D type
weakened D expression
Single missense mutation446C>A (A149D)
19991999
weak D type 54RHD*01W.54
RHD*weak D type 54
Eurasian D clusterweak D type
weakened D expression
Single missense mutation365C>T (S122L)
weak D type 55RHD*01W.55
RHD*weak D type 55
Eurasian D clusterweak D type
weakened D expression
Single missense mutation895C>G (L299V)
2007
weak D type 67RHD*01W.67
RHD*weak D type 67
Eurasian D clusterweak D type
weakened D expression
Single missense mutation722C>T (T241I)
2008
weak D type 88RHD* 01W.88
RHD*weak D type 88
Eurasian D clusterweak D type
weakened D expression
Single missense mutation182G>C (G61A)
2014
weak D type 9RHD*01W.9
RHD*weak D type 9
Eurasian D clusterweak D type
weakened D expression
Single missense mutation880G>C (A294P)
19991999
weak D type 93RHD* 01W.93
RHD*weak D type 93
Eurasian D clusterweak D type
weakened D expression
Single missense mutation359C>A (A120D)
2016