No designation assigned
Eurasian D cluster
First mention in abstract form: 1996 Liu, W., Jones, J.W., Scott, M.L., Voak, D., and Avent, N.D. Molecular analysis of two D-variants, DHMi and DHMii. Transfus.Med. 6(suppl 2):21, 1996. (Abstract)
The existence of a hybrid allele with DHMii phenotype may be doubted: The molecular structure of the hybrid has never been satisfactorily established. DHMii was reported to be associated with an RHD-CE-D hybrid allele in which exons 3, 4 and â??most ofâ?? exon 5 of RHD were replaced by RHCE equivalents. In addition, an intact RHD gene (in trans?) was present, because a PCR detecting RHD intron 4 was positive. A more definitive study resolving these discrepancies and detailing the extension of the gene conversion is pending. Instead, a sample serologically similar to DHMii was characterized as DNS, while the RHD-CE(3-5)-D allele has been characterized as DVI type 4 associated with a DVI phenotype.
Last update: 2012-03-27 (yyyy-MM-dd)