RHD(W16R)

Structure

RHD(W16R)

Key changes from standard allele

46T>C (W16R)

ISBT allele designation

RHD*01EL.43
RHD*DEL43

Nucleotide changes relative to "standard RHD"

c.46 T>C

Amino acid changes relative to standard protein

Trp to Arg at codon 16

W16R

ISBT group

DEL

Phenotype characterization and grouping

DEL

Phenotypes observed

cDEe (major)

Haplotype (typical)

cDE

Allele cluster

Eurasian D cluster

Descriptions

First submission to GenBank: 2012 HE999546 (submitted 2012-10-03, released 2012-10-28)

Serology

DEL HE999546
extremely weak antigen D expression Trucco Boggione C et. al. Transfusion. 2014 Oct;54(10):2456-62. doi: 10.1111/trf.12691. Epub 2014 May 12.

Observations

Argentina: Rosario : 5 of 1314 D negative samples; 5 of 31 D negative samples with ccEe phenotype. In 2 of 5 samples linked to RHcE(697C>G, 712A> G, 733C>G, 744T>C) Trucco Boggione C et. al. Transfusion. 2014 Oct;54(10):2456-62. doi: 10.1111/trf.12691. Epub 2014 May 12.
Switzerland (general): HE999546

Additional comments

Last update: 2018-12-02 (yyyy-MM-dd)