weak D type 4.0.1

Structure

RHD(T201R,F223V)

Key changes from standard allele

602C>G (T201R)
667T>G (F223V)

ISBT allele designation

RHD*09.03
RHD*DAR3

Nucleotide changes relative to "standard RHD"

c.[602 C>G;667 T>G]

Amino acid changes relative to standard protein

T201R, F223V

Haplotype (typical)

cDe

Allele cluster

weak D type 4 cluster

Descriptions

Other relevant descriptions:
Tax MGHM Rh variability in multi-ethnic perspective (thesis)

ISBT group

partial RHD

Phenotype characterization and grouping

weak D type; weakened D expression; Partial D

Serology

No data

Observations

Brazaville and Teke groups: Observed in 2 of 40 D+ samples Touinssi M et. al. Transfusion. 2009 Jul;49(7):1353-60.

Related Alleles

Ccdes-1 [RHD(L62F,A137V,N152T)-RHCE(4-7)-RHD(G336C)]
Ccdes-2 [RHD-RHCE(4-7)-RHD(G336C)]
DIIIa-ceS(1-2)-D(3)-ceS(4-7)-D [DIIIa-ceS(1-2)-D(3)-ceS(4-7)-D]
DVI type 2 [RHD-RHCE(4-6)-RHD]
RHD(A137V,N152T)-CE(4-6)-D(7-10) [RHD(A137V,N152T)-CE(4-6)-D(7-10)]
DVI type 1 [RHD-RHcE(4-5)-RHD]
DAR1 (weak D type 4.2.0) [RHD(T201R,F223V,I342T)]
DAR(CE2:V50V-S68N) [RHD(150T>C,178A>C,201G>A,203G>A,602C>G,667T>G,957G>A,1025T>C)]
DAR(T203A) [RHD(T201R,T203A,F223V,I342T)]
DAR-E [RHD(T201R,F223V,E233Q,I342T)[957G>A]]
DAR2.1 [RHD(T201R,F223V,E233Q,I342T)[744C>T, 957G>A]]
DIII type 5 [RHD(L62F,A137V,N152T,T201R,F223V)]
DIII type 6 [RHD(A137V,N152T,T201R,F223V,A273A)]
DIII type 7 [RHD-RHCE(2)-RHD(A137V,N152T,T201R,F223V)]
DIIIa150C [RHD(150T>C,L62F,A137V,N152T,T201R,F223V,819G>A)]
RHD(I60L,N152T,T201R,F223V,G263R) [RHD(I60L,N152T,T201R,F223V,G263R)]
weak D type 4.4 [RHD(K198N,T201R,F223V)]
RHD(N152T,T201R,F223V) [RHD(N152T,T201R,F223V)]
RHD(T201R)-CE(5)-D(I342T) [RHD(T201R)-CE(5)-D(I342T)]
RHD(T201R,F223V,G307R) [RHD(T201R,F223V,G307R)]
weak D type 4.5 [RHD(T201R,F223V,G355S)]
RHD(T201R,F223V,K264N,A273A) [RHD(T201R,F223V,K264N,A273A)]
RHD-RHCE(3)--weak D type 4.0 [RHD-RHCE(3)-RHD(T201R,F223V,819G>A)]
weak D type 4.0 [RHD(T201R,F223V)[819G>A]]
weak D type 4.1 [RHD(W16C,T201R,F223V)]
weak D type 4.2.1 (DAR1.1) [RHD(T201R,F223V,,I342T)[957G>A]]
weak D type 4.2.2 (DAR1.2) [RHD(T201R,F223V,I342T)[744C>T,957G>A]]
weak D type 4.2.3 (DAR1.3) [RHD(T201R,F223V,I342T)[744C]]
weak D type 4.3 [RHD(T201R,F223V,P291R)[819G>A]]
DVI type 4 [RHD-RHCE(3-5)-RHD]
DVI type 3 [RHD-RHCE(3-6)-RHD]
DVI type 3.2 [RHD-RHCE(3-6)-RHD(A399T)]
RHCE(1-9)-RHD [RHCE(1-9)-RHD]
RHD-RHCE(2-10) [RHD-RHCE(2-10)]
RHD-RHCe(2-7)-RHD [RHD-RHCE(3-7)-RHD]
RHD(L110P)-CE(3-9)-D [RHD(L110P)-CE(3-9)-D]
RHD(S68T)-RHCe(3-9)-RHD [RHD(S68T)-RHCE(3-9)-RHD]
RHD-RHCe(2-9)-RHD [RHD-RHCe(2-9)-RHD]
RHD-RHCe(2-9)-RHD1 [RHD-RHCE(3-9)-RHD]
RHD-RHCe(2-9)-RHD2 [RHD-RHCE(3-9)-RHD]
RHD-RHCE(4-7)-RHD [RHD-RHCE(4-7)-RHD]
RHD-RHCE(4-7)-RHD1 [RHD-RHCE(4-7)-RHD]
RHD-RHCE(4-7)-RHD2 [RHD-RHCE(4-7)-RHD]
RHD-RHCE(4-8)-RHD [RHD-RHCE(4-7)-RHD]
RHD-RHCE(4-9)-RHD [RHD-RHCE(4-9)-RHD]
RHD-RHCE(2-5)-RHD [RHD-RHCE(2-5)-RHD]

Additional comments

ISBT listing as of v4.1

Last update: 2017-01-29 (yyyy-MM-dd)