RHD-RHCe(2-9)-RHD1

Structure

RHD-RHCE(3-9)-RHD

Caution: This structure most likely does not exist

Key changes from standard allele

Hybrid RHCE(3-9)

ISBT allele designation

No designation assigned

Nucleotide changes relative to "standard RHD"

c.[361 T>A;380 T>C;383 A>G;455 A>C;505 A>C;509 T>G;514 A>T;544 T>A;577 G>A;594 A>T;602 C>G;667 T>G;697 G>C;712 G>A;733 G>C;744 C>T;787 G>A;800 A>T;916 G>A;932 A>G;941 G>T;968 C>A;974 G>T;979 A>G;985 GG>CA;989 A>C;992 A>T;1025 T>C;1048 G>C;1053 C>T;1057 GGA>TGG;1060 GC>AA;1170 T>C;1193 A>T]

Amino acid changes relative to standard protein

L121M, V127A, D128G, N152T, M169L, M170R, I172F, S182T, E193K, K198N, T201R, F223V, E233Q, V238M, V245L, G263R, K267M, V306I, Y311C, G314V, P323H, S325I, I327V, G329H, Y330S, N331I, I342T, D350H, G353W, A354N, E398V

Haplotype (typical)

CDe

Allele cluster

Eurasian D cluster

Descriptions

Other relevant descriptions:
Wagner FF et. al. BMC Genet. 2001;2:10. Epub 2001 Jul 16.

ISBT group

Phenotype characterization and grouping

D negative

Serology

D negative Wagner FF et. al. BMC Genet. 2001;2:10. Epub 2001 Jul 16.

Observations

Korea (south, general): 0.3 % of D negative alleles Kim JY et. al. Transfusion. 2005 Mar;45(3):345-52.
South-Western Germany: Wagner FF et. al. BMC Genet. 2001;2:10. Epub 2001 Jul 16. Frequency 1:15.152
China (general): Shao CP et. al. Vox Sang. 2002 Aug;83(2):156-61.
Ljubljana region: Gassner C et. al. Transfusion. 2005 Apr;45(4):527-38.
Northern Germany: Gassner C et. al. Transfusion. 2005 Apr;45(4):527-38.
Tyrol: Gassner C et. al. Transfusion. 2005 Apr;45(4):527-38.

Related Alleles

RHCE(1-9)-RHD [RHCE(1-9)-RHD]
RHD-RHCE(2-10) [RHD-RHCE(2-10)]
RHD(L110P)-CE(3-9)-D [RHD(L110P)-CE(3-9)-D]
RHD(S68T)-RHCe(3-9)-RHD [RHD(S68T)-RHCE(3-9)-RHD]
RHD-RHCe(2-9)-RHD [RHD-RHCe(2-9)-RHD]
RHD-RHCe(2-9)-RHD2 [RHD-RHCE(3-9)-RHD]

Additional comments

This allele in unlikely to exist. Samples assigned to this allele most likely represented RHD-RHCe(2-9)-RHDRHCE-like polymorphisms were found in intron 1 and intron 9. The described features of this allele are compatible with the original description of RHD-RHCe(2-9)-RHD.

Last update: 2012-03-25 (yyyy-MM-dd)