RHD-RHCe(2-9)-RHD2

Structure

RHD-RHCE(3-9)-RHD

Caution: This structure most likely does not exist

Key changes from standard allele

Hybrid RHCE(3-9)

ISBT allele designation

No designation assigned

Nucleotide changes relative to "standard RHD"

c.[361 T>A;380 T>C;383 A>G;455 A>C;505 A>C;509 T>G;514 A>T;544 T>A;577 G>A;594 A>T;602 C>G;667 T>G;697 G>C;712 G>A;733 G>C;744 C>T;787 G>A;800 A>T;916 G>A;932 A>G;941 G>T;968 C>A;974 G>T;979 A>G;985 GG>CA;989 A>C;992 A>T;1025 T>C;1048 G>C;1053 C>T;1057 GGA>TGG;1060 GC>AA;1170 T>C;1193 A>T]

Amino acid changes relative to standard protein

L121M, V127A, D128G, N152T, M169L, M170R, I172F, S182T, E193K, K198N, T201R, F223V, E233Q, V238M, V245L, G263R, K267M, V306I, Y311C, G314V, P323H, S325I, I327V, G329H, Y330S, N331I, I342T, D350H, G353W, A354N, E398V

ISBT group

Phenotype characterization and grouping

D negative

Haplotype (typical)

CDe

Allele cluster

Eurasian D cluster

Descriptions

Other relevant descriptions:
Wagner FF et. al. BMC Genet. 2001;2:10. Epub 2001 Jul 16.

Serology

D negative Wagner FF et. al. BMC Genet. 2001;2:10. Epub 2001 Jul 16.

Observations

South-Western Germany: Wagner FF et. al. BMC Genet. 2001;2:10. Epub 2001 Jul 16. Frequency 1:5.682

Related Alleles

RHCE(1-9)-RHD [RHCE(1-9)-RHD]
RHD-RHCE(2-10) [RHD-RHCE(2-10)]
RHD(L110P)-CE(3-9)-D [RHD(L110P)-CE(3-9)-D]
RHD(S68T)-RHCe(3-9)-RHD [RHD(S68T)-RHCE(3-9)-RHD]
RHD-RHCe(2-9)-RHD [RHD-RHCe(2-9)-RHD]
RHD-RHCe(2-9)-RHD1 [RHD-RHCE(3-9)-RHD]

Additional comments

This allele in unlikely to exist. Samples assigned to this allele most likely represented RHD(S68T)-RHCe(3-9)-RHDThis allele was characterized as PCR pattern only. It differed from RHD-RHCe(2-9)-RHD₁ by an RHD-derived intron 1. It is probably identical to RHD(S68T)-RHCe(3-9)-RHD, observations are listed under that allele.

Last update: 2012-03-25 (yyyy-MM-dd)