DIIIa-ceS(1-2)-D(3)-ceS(4-7)-D

Structure

DIIIa-ceS(1-2)-D(3)-ceS(4-7)-D

Key changes from standard allele

1006G>T (G336C)
410C>T (A137V)
455A>C (N152T)
48G>C (W16C)
Hybrid RHCE(2)
Hybrid RHCE[245V](4-7)

ISBT allele designation

No designation assigned

Nucleotide changes relative to "standard RHD"

c.[48 G>C;150 T>C;178 A>C;201 G>A;203 G>A;307 T>C;410 C>T;455 A>C;505 A>C;509 T>G;514 A>T;544 T>A;577 G>A;594 A>T;602 C>G;667 T>G;697 G>C;712 G>A;744 C>T;787 G>A;800 A>T;916 G>A;932 A>G;941 G>T;968 C>A;974 G>T;979 A>G;985 GG>CA;989 A>C;992 A>T;1006 G>T;1025 T>C;1048 G>C;1053 C>T;1057 GGA>TGG;1060 GC>AA]

Amino acid changes relative to standard protein

W16C, I60L, S68N, S103P, A137V, N152T, M169L, M170R, I172F, S182T, E193K, K198N, T201R, F223V, E233Q, V238M, G263R, K267M, V306I, Y311C, G314V, P323H, S325I, I327V, G329H, Y330S, N331I, G336C, I342T, D350H, G353W, A354N

Haplotype (typical)

not reported

Allele cluster

DIVa cluster

Descriptions

First submission to GenBank: 2017 KY926710 (submitted 2017-04-10, released 2017-07-22)

ISBT group

Phenotype characterization and grouping

Serology

No data

Observations

No data

Additional comments

According to the author, exon 1 is RHCE-derived.

Last update: 2018-02-06 (yyyy-MM-dd)