RHD(I60L,N152T,T201R,F223V,G263R)

Structure

RHD(I60L,N152T,T201R,F223V,G263R)

Caution: This structure most likely does not exist

Key changes from standard allele

1170T>C
178A>C (I60L)
455A>C (N152T)
602C>G (T201R)
667T>G (F223V)
744C>T
787G>A (G263R)

ISBT allele designation

No designation assigned

Nucleotide changes relative to "standard RHD"

c.[178 A>C;455 A>C;602 C>G;667 T>G;744 C>T;787 G>A;1170 T>C]

Amino acid changes relative to standard protein

I60L, N152T, T201R, F223V, G263R

Haplotype (typical)

cDe

Allele cluster

DIVa cluster

Descriptions

First submission to GenBank: 1999 AF187846 (submitted 1999-09-18, released 1999-10-31)

ISBT group

Phenotype characterization and grouping

Partial D

Serology

No data

Observations

African ancestry (general): 60 DIIIa samples including the original ones did not possess this structure Westhoff CM et. al. Transfusion. 2010 Jun;50(6):1303-11. Epub 2010 Jan 15.

Additional comments

This allele in unlikely to exist. Samples assigned to this allele most likely represented DIII type 5This structure is the structure originally submitted to GenBank as underlying the DIIIa phenotype. It is likely non-existent, since the original samples were later shown to contain a structure previously described as DIII type 5.

Last update: 2012-03-25 (yyyy-MM-dd)