DIII type 5

Structure

RHD(L62F,A137V,N152T,T201R,F223V)

Key changes from standard allele

186G>T (L62F)
410C>T (A137V)
455A>C (N152T)
602C>G (T201R)
667T>G (F223V)
819G>A

ISBT allele designation

RHD*03.01
RHD*DIIIa

Nucleotide changes relative to "standard RHD"

c.[186 G>T;410 C>T;455 A>C;602 C>G;667 T>G;819 G>A]

Amino acid changes relative to standard protein

L62F, A137V, N152T, T201R, F223V, A273A

Haplotype (typical)

cDe

Allele cluster

DIVa cluster

Descriptions

First full publication: 2002 Wagner FF et. al. Blood. 2002 Jul 1;100(1):306-11. (submitted 2002-01-31, released 2002-06-19)

Other relevant descriptions:
DIII type 5 is the molecular structure underlying the DIIIa phenotype Westhoff CM et. al. Transfusion. 2010 Jun;50(6):1303-11. Epub 2010 Jan 15.

ISBT group

partial RHD

Phenotype characterization and grouping

Partial D; D category

Serology

hrB negative, HrB negative Pham BN et. al. Transfusion. 2009 Mar;49(3):495-504.

Observations

French of African ancestry: 2 of 280 D pos donors, in addition 2 alleles in heterozygous state; linked to RHCE*ces1006 in 5 donors Kappler-Gratias S et. al. Blood Transfus. 2014 Jan;12 Suppl 1:s264-72. doi: 10.2450/2013.0270-12. Epub 2013
African American: SWiTCH trial Chou ST et. al. Blood Adv. 2017 Aug 3;1(18):1414-1422. doi: 10.1182/bloodadvances.2017007898. Frequency 1:0,019

Related Alleles

DIIIa150C [RHD(150T>C,L62F,A137V,N152T,T201R,F223V,819G>A)]

Additional comments

This allele is underlying most to all DIIIa phenotypes. The "obsolete" designation DIII type 5 is used for listing purposes, because the designation DIIIa allele recommended by ISBT in the literature has been used for a multitude of alleles in the literature.

Last update: 2018-04-23 (yyyy-MM-dd)