weak D type 4.3

Structure

RHD(T201R,F223V,P291R)[819G>A]

Key changes from standard allele

602C>G (T201R)
667T>G (F223V)
819G>A
872C>G (P291R)

ISBT allele designation

RHD*09. 05
RHD*weak 4.3

Nucleotide changes relative to "standard RHD"

602 C>G, 667 T>G, 819 G>A, 872 C>G

Amino acid changes relative to standard protein

T201R, F223V, A273A, P291R

Haplotype (typical)

cDe

Allele cluster

weak D type 4 cluster

Descriptions

First mention in abstract form: 2004 Flegel WA & et al. Blood (ASH Annual Meeting Abstracts) 2004 104: Abstract 2706

ISBT group

partial RHD

Phenotype characterization and grouping

weak D type; DEL; weakened D expression; Partial D

Serology

No data

Observations

Linz region: Flegel WA & et al. Blood (ASH Annual Meeting Abstracts) 2004 104: Abstract 2706
Linz region: Polin H et. al. Transfusion. 2007 Aug;47(8):1350-5.

Additional comments

very weak D phenotype, often appears as DEL This allele is obviously more related to weak D type 4.0 than to DAR (weak D type 4.2), the phenotype resembles neither weak D type 4.0 nor DAR (weak D type 4.2). The partial D status is putative.

Last update: 2017-01-29 (yyyy-MM-dd)