weak D type 4.4

Structure

RHD(K198N,T201R,F223V)

Key changes from standard allele

594A>T (K198N)
602C>G (T201R)
667T>G (F223V)
819G>A

ISBT allele designation

No designation assigned

Nucleotide changes relative to "standard RHD"

c.[594 A>T;602 C>G;667 T>G;819 G>A]

Amino acid changes relative to standard protein

K198N, T201R, F223V, A273A

Haplotype (typical)

not reported

Allele cluster

weak D type 4 cluster

Descriptions

First submission to GenBank: 2016 KU363616 (submitted 2015-12-29, released 2016-03-12)

First full publication: 2017 Floch A et. al. Transfusion. 2017 Apr;57(4):1089-1091. doi: 10.1111/trf.14004. Epub 2017 Jan 28.

ISBT group

Phenotype characterization and grouping

weak D type

Serology

No data

Observations

No data

Additional comments

Sequence KU363616 is denoted RHD*594T in the submission but contains the four mutations listed and therefore might represent a weak D type 4 variant.

Last update: 2016-07-22 (yyyy-MM-dd)