weak D type 4.2.3 (DAR1.3)

Structure

RHD(T201R,F223V,I342T)[744C]

Key changes from standard allele

1025T>C (I342T)
602C>G (T201R)
667T>G (F223V)
744C>T

ISBT allele designation

RHD*09.01.03
RHD*DAR1.03

Nucleotide changes relative to "standard RHD"

602 C>G, 667 T>G, 744 C>T, 1025 T>C

Amino acid changes relative to standard protein

T201R, F223V, I342T

Haplotype (typical)

cDe

Allele cluster

weak D type 4 cluster

Descriptions

First submission to GenBank: 2008 AM930980 (submitted 2007-12-19, released 2008-01-31)

Other relevant descriptions:
Rhesus immunization registry

ISBT group

partial RHD

Phenotype characterization and grouping

weak D type; Partial D; weakened D expression

Serology

754 â?? 1,542 antigens/cell (2 samples, 22 to 50 antibodies, 12 laboratories) Rhesus Index 0.33 â?? 0.78 (2 samples, 22 to 50 antibodies, 12 laboratories) weak D type 4.2 subtype not specified Flegel WA et. al. Transfus Clin Biol. 2002 Jan;9(1):33-42.

Observations

Brazaville and Teke groups: Observed in 1 of 40 D positive samples Touinssi M et. al. Transfusion. 2009 Jul;49(7):1353-60.

Additional comments

ISBT listing according to v4.1. In earlier versions, this allele was listed as RHD*09.01.02

Last update: 2017-01-29 (yyyy-MM-dd)