weak D type 100

Structure

RHD(G263R)

Key changes from standard allele

787G>A (G263R)

ISBT allele designation

RHD* 01W.100
RHD*weak D type 100

Nucleotide changes relative to "standard RHD"

787 G>A

Amino acid changes relative to standard protein

Gly to Arg at codon 263

G263R

Haplotype (typical)

CDe

Allele cluster

Eurasian D cluster

Descriptions

First submission to GenBank: 2010 FJ041199 (submitted 2008-08-17, released 2010-01-01)

Other relevant descriptions:
GU998826 (submitted 2010-03-12, released 2010-04-28)
LC053443 (submitted 2015-04-28, released 2015-06-04)
Ogasawara K et. al. Vox Sang. 2015 Sep 4. doi: 10.1111/vox.12322.

ISBT group

weak D

Phenotype characterization and grouping

weak D type; weakened D expression

Serology

weak D expression: direct agglutination 2+ to 3+, IAT 4+ Ogasawara K et. al. Vox Sang. 2015 Sep 4. doi: 10.1111/vox.12322.

Observations

African ancestry (general): 5 of 45 samples with weak D expression; associated with CDe haplotype Ogasawara K et. al. Vox Sang. 2015 Sep 4. doi: 10.1111/vox.12322.
China (general): FJ041199
Szichuan: GU998826

Additional comments

Last update: 2017-02-12 (yyyy-MM-dd)