weak D type 100

Structure

RHD(G263R)

Key changes from standard allele

787G>A (G263R)

ISBT allele designation

RHD* 01W.100
RHD*weak D type 100

Nucleotide changes relative to "standard RHD"

c.787 G>A

Amino acid changes relative to standard protein

Gly to Arg at codon 263

G263R

Haplotype (typical)

CDe

Allele cluster

Eurasian D cluster

Descriptions

First submission to GenBank: 2010 FJ041199 (submitted 2008-08-17, released 2010-01-01)

Other relevant descriptions:
GU998826 (submitted 2010-03-12, released 2010-04-28)
LC053443 (submitted 2015-04-28, released 2015-06-04)
Ogasawara K et. al. Vox Sang. 2015 Sep 4. doi: 10.1111/vox.12322.

ISBT group

weak D

Phenotype characterization and grouping

weak D type; weakened D expression

Serology

weak D expression: direct agglutination 2+ to 3+, IAT 4+ Ogasawara K et. al. Vox Sang. 2015 Sep 4. doi: 10.1111/vox.12322.

Observations

Japan (general): 5 of 45 samples with weak D expression; associated with CDe haplotype Ogasawara K et. al. Vox Sang. 2015 Sep 4. doi: 10.1111/vox.12322.
China (general): FJ041199
Szichuan: GU998826

Related Alleles

Ccdes-1 [RHD(L62F,A137V,N152T)-RHCE(4-7)-RHD(G336C)]
Ccdes-2 [RHD-RHCE(4-7)-RHD(G336C)]
DIIIa-ceS(1-2)-D(3)-ceS(4-7)-D [DIIIa-ceS(1-2)-D(3)-ceS(4-7)-D]
DVI type 2 [RHD-RHCE(4-6)-RHD]
RHD(A137V,N152T)-CE(4-6)-D(7-10) [RHD(A137V,N152T)-CE(4-6)-D(7-10)]
DVI type 1 [RHD-RHcE(4-5)-RHD]
DBS-1 [RHD-RHcE(5:667-5:800)-RHD]
DBT-1 [RHD-RHCe(5-7)-RHD]
DBT-2 [RHD-RHCe(5-9)-RHD]
DBU [RHD-cE(5-7;226P)-D]
DVI type 4 [RHD-RHCE(3-5)-RHD]
RHD(G263R,A399T) [RHD(G263R,A399T)]
RHD(I60L,N152T,T201R,F223V,G263R) [RHD(I60L,N152T,T201R,F223V,G263R)]
RHD(V245L,G263R,K267M) [RHD(V245L,G263R,K267M)]
DV type 2 [RHD-RHCE(5)-RHD]
RHD(T201R)-CE(5)-D(I342T) [RHD(T201R)-CE(5)-D(I342T)]
DV type 7 [RHD-RHCE(5:667-5:787)-RHD]
DVI type 3 [RHD-RHCE(3-6)-RHD]
DVI type 3.2 [RHD-RHCE(3-6)-RHD(A399T)]
DV type 10 [RHD-RHCE(5-6)-RHD]
DLX [RHD(F223V)-RHCE(5:712-6)-RHD]
RHCE(1-9)-RHD [RHCE(1-9)-RHD]
RHD-RHCE(2-10) [RHD-RHCE(2-10)]
RHD-RHCe(2-7)-RHD [RHD-RHCE(3-7)-RHD]
RHD(L110P)-CE(3-9)-D [RHD(L110P)-CE(3-9)-D]
RHD(S68T)-RHCe(3-9)-RHD [RHD(S68T)-RHCE(3-9)-RHD]
RHD-RHCe(2-9)-RHD [RHD-RHCe(2-9)-RHD]
RHD-RHCe(2-9)-RHD1 [RHD-RHCE(3-9)-RHD]
RHD-RHCe(2-9)-RHD2 [RHD-RHCE(3-9)-RHD]
RHD-RHCE(4-7)-RHD [RHD-RHCE(4-7)-RHD]
RHD-RHCE(4-7)-RHD1 [RHD-RHCE(4-7)-RHD]
RHD-RHCE(4-7)-RHD2 [RHD-RHCE(4-7)-RHD]
RHD-RHCE(4-8)-RHD [RHD-RHCE(4-7)-RHD]
RHD-RHCE(4-9)-RHD [RHD-RHCE(4-9)-RHD]
RHD-cE(5-6)-D [RHD-cE(5-6)-D]
RHD-RHCE(5:733-5:787)-RHD [RHD-RHCE(5:733-5:787)-RHD]
RHD-RHCE[245V](5)-RHD [RHD-RHCE[245V](5)-RHD]
RHD-RHCE(2-5)-RHD [RHD-RHCE(2-5)-RHD]

Additional comments

Last update: 2018-02-25 (yyyy-MM-dd)