RHD(V306I,Y311C)

Structure

RHD(V306I,Y311C)

Key changes from standard allele

916G>A (V306I)
932A>G (Y311C)

ISBT allele designation

No designation assigned

Nucleotide changes relative to "standard RHD"

c.[916 G>A;932 A>G]

Amino acid changes relative to standard protein

V306I, Y311C

Haplotype (typical)

not reported

Allele cluster

Eurasian D cluster

Descriptions

First submission to GenBank: 2016 LT596154 (submitted 2016-05-24, released 2016-06-30)

ISBT group

Phenotype characterization and grouping

Serology

No data

Observations

No data

Related Alleles

Ccdes-1 [RHD(L62F,A137V,N152T)-RHCE(4-7)-RHD(G336C)]
Ccdes-2 [RHD-RHCE(4-7)-RHD(G336C)]
DIIIa-ceS(1-2)-D(3)-ceS(4-7)-D [DIIIa-ceS(1-2)-D(3)-ceS(4-7)-D]
DVI type 2 [RHD-RHCE(4-6)-RHD]
RHD(A137V,N152T)-CE(4-6)-D(7-10) [RHD(A137V,N152T)-CE(4-6)-D(7-10)]
DBT-1 [RHD-RHCe(5-7)-RHD]
DBT-2 [RHD-RHCe(5-9)-RHD]
DBU [RHD-cE(5-7;226P)-D]
DHAR [RHCE-RHD(5)-RHCE]
DIV type 3 [RHD-RHCE(6-9)-RHD]
DVI type 3 [RHD-RHCE(3-6)-RHD]
DVI type 3.2 [RHD-RHCE(3-6)-RHD(A399T)]
DV type 10 [RHD-RHCE(5-6)-RHD]
DLX [RHD(F223V)-RHCE(5:712-6)-RHD]
RHCE(1-9)-RHD [RHCE(1-9)-RHD]
RHD-RHCE(2-10) [RHD-RHCE(2-10)]
RHD-RHCe(2-7)-RHD [RHD-RHCE(3-7)-RHD]
RHD(L110P)-CE(3-9)-D [RHD(L110P)-CE(3-9)-D]
RHD(S68T)-RHCe(3-9)-RHD [RHD(S68T)-RHCE(3-9)-RHD]
RHD-RHCe(2-9)-RHD [RHD-RHCe(2-9)-RHD]
RHD-RHCe(2-9)-RHD1 [RHD-RHCE(3-9)-RHD]
RHD-RHCe(2-9)-RHD2 [RHD-RHCE(3-9)-RHD]
RHD-RHCE(4-7)-RHD [RHD-RHCE(4-7)-RHD]
RHD-RHCE(4-7)-RHD1 [RHD-RHCE(4-7)-RHD]
RHD-RHCE(4-7)-RHD2 [RHD-RHCE(4-7)-RHD]
RHD-RHCE(4-8)-RHD [RHD-RHCE(4-7)-RHD]
RHD-RHCE(4-9)-RHD [RHD-RHCE(4-9)-RHD]
weak D type 2.2 [RHD(V306I,Y311C,G385A)]
RHD-cE(5-6)-D [RHD-cE(5-6)-D]

Additional comments

Due to an error during submission, the sequence shown in LT596154.1 displays a 873G>A rather than a 916G>A substitution. In a personal communication, the author sent the original electropherogram of exon 6 which shows that the substitutions are 916'GYA and 932A>G and that these subsitutions are part of a RHCE-like sequence segment that extends at least 136 bp into IVS6.

Last update: 2017-12-31 (yyyy-MM-dd)