weak D type 4 cluster

DesignationISBT nameHaplotypePhenotypeMechanismAlterationsFirst mentionDefinitive publication
DAR1 (weak D type 4.2.0)RHD*09.01.00
RHD*DAR1.00
cDePartial D
weak D type
weakened D expression
Multiple missense mutations1025T>C (I342T)
602C>G (T201R)
667T>G (F223V)
19981999
DAR(CE2:V50V-S68N)RHD*09.06
RHD*DAR6
RHD*DAR(SE2:v50V-S68N)
cDePartial DComplex changes1025T>C (I342T)
150T>C
178A>C (I60L)
201G>A
203G>A (S68N)
602C>G (T201R)
667T>G (F223V)
957 G>A
2013
DAR(T203A)RHD*09.01
RHD*DAR
cDePartial DMultiple missense mutations1025T>C (I342T)
602C>G (T201R)
607A>G (T203A)
667T>G (F223V)
744C>T
957 G>A
20122012
DAR-ERHD*09.02
RHD*DAR2
cDePartial D
weakened D expression
Multiple missense mutations1025T>C (I342T)
602C>G (T201R)
667T>G (F223V)
697G>C (E233Q)
957 G>A
20062006
DAR2.1RHD*09.02.01
RHD*DAR2.01
not reportedPartial DMultiple missense mutations1025T>C (I342T)
602C>G (T201R)
667T>G (F223V)
697G>C (E233Q)
744C>T
957 G>A
DFVRHD*08.01
RHD*DFV
multiplePartial DSingle missense mutation667T>G (F223V)
20022002
DFV.1cDeweakened D expressionSingle missense mutation667T>G (F223V)
819G>A
20132014
DOL-1RHD*12.01
RHD*DOL1
cDePartial DMultiple missense mutations509T>C (M170T)
667T>G (F223V)
19992009
DOL-2RHD*12.02
RHD*DOL2
not reportedPartial DMultiple missense mutations1132C>G (L378V)
509T>C (M170T)
667T>G (F223V)
20052009
DOL-3RHD*12.03
RHD*DOL3
not reportedPartial DMultiple missense mutations410C>T (A137V)
509T>C (M170T)
667T>G (F223V)
2005
DTORHD*30
RHD*DTO
not reportedweakened D expression
Partial D
Multiple missense mutations667T>G (F223V)
674C>T (S225F)
20052005
RHD psiRHD*08N.01
RHD*Pseudogene
cDeD negativeComplex changes609G>A
654G>C (M218I)
667T>G (F223V)
674C>T (S225F)
807T>G (Y269X)
IVS3-19 dupl 37
20002000
RHD(F223V,G278V)not reportedD positive (no further data)Multiple missense mutations667T>G (F223V)
833G>T (G278V)
20122012
weak D type 4.4not reportedweak D typeMultiple missense mutations594A>T (K198N)
602C>G (T201R)
667T>G (F223V)
819G>A
2016
RHD(M218I, F223V, S225F,Y269X)not reportedD negativeComplex changes609G>A
654G>C (M218I)
667T>G (F223V)
674C>T (S225F)
807T>G (Y269X)
2009
RHD(T201R,F223V,G307R)not reportedD positive (no further data)Multiple missense mutations602C>G (T201R)
667T>G (F223V)
819G>A
919G>A (G307R)
20122012
weak D type 4.5not reportedweak D typeMultiple missense mutations1063G>A (G355S)
602C>G (T201R)
667T>G (F223V)
819G>A
2016
RHD-RHCE(3)--weak D type 4.0RHD*01N.72not reportedD negativehybrid allele602C>G (T201R)
667T>G (F223V)
819G>A
Hybrid RHCE(3)
RHDpsi-OT1cDeComplex changes609G>A
654G>C (M218I)
667T>G (F223V)
674C>T (S225F)
835G>A (V279M)
IVS3-19 dupl 37
IVS7-214ins ACAG
2012
weak D type 29RHD*01W.29
RHD*weak D type 29
cDeweak D type
weakened D expression
Multiple missense mutations1025T>C (I342T)
178A>C (I60L)
201G>A
203G>A (S68N)
594A>T (K198N)
667T>G (F223V)
744C>T
957 G>A
20032003
RHD(I60L,S68N,K198N,F223V,G314V,I342T)not reportedweak D type
weakened D expression
Multiple missense mutations1025T>C (I342T)
178A>C (I60L)
201G>A
203G>A (S68N)
594A>T (K198N)
667T>G (F223V)
744C>T
941G>T (G314V)
2010
weak D type 4.0RHD*09.03.01
RHD*DAR3
cDeweak D type
weakened D expression
Partial D
Multiple missense mutations602C>G (T201R)
667T>G (F223V)
819G>A
19991999
weak D type 4.0.1RHD*09.03
RHD*DAR3
cDeweak D type
weakened D expression
Partial D
Multiple missense mutations602C>G (T201R)
667T>G (F223V)
weak D type 4.1RHD*09.04
RHD*DAR4
cDeweak D type
weakened D expression
Multiple missense mutations48G>C (W16C)
602C>G (T201R)
667T>G (F223V)
819G>A
20002000
weak D type 4.2.1 (DAR1.1)RHD*09.01.01
RHD*DAR1.01
RHD*weak 4.2
cDePartial D
weak D type
weakened D expression
Multiple missense mutations1025T>C (I342T)
602C>G (T201R)
667T>G (F223V)
957 G>A
20002000
weak D type 4.2.2 (DAR1.2)RHD*09.01.02
cDePartial D
weak D type
weakened D expression
Multiple missense mutations1025T>C (I342T)
602C>G (T201R)
667T>G (F223V)
744C>T
957 G>A
20002000
weak D type 4.2.3 (DAR1.3)RHD*09.01.03
RHD*DAR1.03
cDeweak D type
Partial D
weakened D expression
Multiple missense mutations1025T>C (I342T)
602C>G (T201R)
667T>G (F223V)
744C>T
2008
weak D type 4.3RHD*09. 05
RHD*weak 4.3
cDeweak D type
DEL
weakened D expression
Partial D
Multiple missense mutations602C>G (T201R)
667T>G (F223V)
819G>A
872C>G (P291R)
2004