RHD(I60L,S68N,K198N,F223V,G314V,I342T)

Structure

RHD(I60L,S68N,K198N,F223V,G314V,I342T)

Key changes from standard allele

1025T>C (I342T)
178A>C (I60L)
201G>A
203G>A (S68N)
594A>T (K198N)
667T>G (F223V)
744C>T
941G>T (G314V)

ISBT allele designation

No designation assigned

Nucleotide changes relative to "standard RHD"

c.[178 A>C;201 G>A;203 G>A;594 A>T;667 T>G;744 C>T;941 G>T;1025 T>C]

Amino acid changes relative to standard protein

I60L, S68N, K198N, F223V, G314V, I342T

Haplotype (typical)

not reported

Allele cluster

weak D type 4 cluster

Descriptions

First submission to GenBank: 2010 FR745438 (submitted 2010-12-06, released 2010-12-23)

ISBT group

Phenotype characterization and grouping

weak D type; weakened D expression

Serology

No data

Observations

No data

Additional comments

This allele differs from weak D type 29 by a G314V substitution and the lack of the silent 957G>A replacement.

Last update: 2012-08-26 (yyyy-MM-dd)