DIV type 4

Structure

RHD-RHCE(7:1048-7:1061)-RHD

Key changes from standard allele

Hybrid RHCE(7:1048-7:1061)

ISBT allele designation

RHD*04.04
RHD*DIV.4

Nucleotide changes relative to "standard RHD"

1048 G>C, 1053 C>T, 1057 GGA>TGG, 1060 GC>AA

Amino acid changes relative to standard protein

D350H, G353W, A354N

Haplotype (typical)

CDe

Allele cluster

Eurasian D cluster

Descriptions

First mention in abstract form: 1998 Wagner FF & et al. Transfusion 38:63S, 1998

First submission to GenBank: 2013 HF549085 (submitted 2012-11-05, released 2013-01-07)

ISBT group

partial RHD

Phenotype characterization and grouping

Partial D; D category

Serology

lacks epitope 1 to 4 and 9 Kormoczi GF et. al. Transfusion. 2005 Oct;45(10):1574-80.
5 probands with anti-D von Zabern I et. al. Transfusion. 2013 Nov;53(11 Suppl 2):2960-73. doi: 10.1111

Observations

Germany (general): von Zabern I et. al. Transfusion. 2013 Nov;53(11 Suppl 2):2960-73. doi: 10.1111

Additional comments

Last update: 2016-08-28 (yyyy-MM-dd)