DIV type 4

Structure

RHD-RHCE(7:1048-7:1061)-RHD

Key changes from standard allele

Hybrid RHCE(7:1048-7:1061)

ISBT allele designation

RHD*04.04
RHD*DIV.4

Nucleotide changes relative to "standard RHD"

c.[1048 G>C;1053 C>T;1057 GGA>TGG;1060 GC>AA]

Amino acid changes relative to standard protein

D350H, G353W, A354N

Haplotype (typical)

CDe

Allele cluster

Eurasian D cluster

Descriptions

First mention in abstract form: 1998 Wagner FF & et al. Transfusion 38:63S, 1998

First submission to GenBank: 2013 HF549085 (submitted 2012-11-05, released 2013-01-07)

ISBT group

partial RHD

Phenotype characterization and grouping

Partial D; D category

Serology

lacks epitope 1 to 4 and 9 Kormoczi GF et. al. Transfusion. 2005 Oct;45(10):1574-80.
5 probands with anti-D von Zabern I et. al. Transfusion. 2013 Nov;53(11 Suppl 2):2960-73. doi: 10.1111

Observations

Germany (general): von Zabern I et. al. Transfusion. 2013 Nov;53(11 Suppl 2):2960-73. doi: 10.1111

Related Alleles

Ccdes-1 [RHD(L62F,A137V,N152T)-RHCE(4-7)-RHD(G336C)]
Ccdes-2 [RHD-RHCE(4-7)-RHD(G336C)]
DIIIa-ceS(1-2)-D(3)-ceS(4-7)-D [DIIIa-ceS(1-2)-D(3)-ceS(4-7)-D]
DBT-1 [RHD-RHCe(5-7)-RHD]
DBT-2 [RHD-RHCe(5-9)-RHD]
DBU [RHD-cE(5-7;226P)-D]
DHAR [RHCE-RHD(5)-RHCE]
DIV type 3 [RHD-RHCE(6-9)-RHD]
DIV type 5 [RHD-RHCE(7-9)-RHD]
DIVb (J) [RHD-RHCE(7-9)-RHD]
DIVb type 2 [RHD-RHCE(7:1048-9)-RHD]
RHCE(1-9)-RHD [RHCE(1-9)-RHD]
RHD-RHCE(2-10) [RHD-RHCE(2-10)]
RHD-RHCe(2-7)-RHD [RHD-RHCE(3-7)-RHD]
RHD(L110P)-CE(3-9)-D [RHD(L110P)-CE(3-9)-D]
RHD(S68T)-RHCe(3-9)-RHD [RHD(S68T)-RHCE(3-9)-RHD]
RHD-RHCe(2-9)-RHD [RHD-RHCe(2-9)-RHD]
RHD-RHCe(2-9)-RHD1 [RHD-RHCE(3-9)-RHD]
RHD-RHCe(2-9)-RHD2 [RHD-RHCE(3-9)-RHD]
RHD-RHCE(4-7)-RHD [RHD-RHCE(4-7)-RHD]
RHD-RHCE(4-7)-RHD1 [RHD-RHCE(4-7)-RHD]
RHD-RHCE(4-7)-RHD2 [RHD-RHCE(4-7)-RHD]
RHD-RHCE(4-8)-RHD [RHD-RHCE(4-7)-RHD]
RHD-RHCE(4-9)-RHD [RHD-RHCE(4-9)-RHD]
RHD(L214F)-CE(7)-D [RHD(L214F)-CE(7)-D]
RHD-RHCE(7)-RHD [RHD-RHCE(7)-RHD]

Additional comments

Last update: 2016-08-28 (yyyy-MM-dd)