D negative

DesignationISBT nameClusterHaplotypeMechanismAlterationsFirst mentionDefinitive publication
Ccdes-1RHD*03N.01
DIVa clusterCcdeComplex changes1006G>T (G336C)
186G>T (L62F)
410C>T (A137V)
455A>C (N152T)
Hybrid RHCE[245V](4-7)
20042004
Ccdes-2RHD*01N.06
DIVa clusterCcdehybrid allele1006G>T (G336C)
Hybrid RHCE[245V](4-7)
20092009
RHCE(1)-D(6)-CE(7-10)RHD*01N.42no RHDCdelarge deletion20022002
RHCE(1-3)-RHD(4-10)RHD*01N.43Eurasian D clustercDEhybrid alleleHybrid RHCE(1-3)
20042009
RHCE(1-9)-RHDRHD*01N.02Eurasian D clustercDEhybrid alleleHybrid RHCE(1-9)
20012001
RHD deletionRHD*01N.01
no RHDcdelarge deletionRHD deletion
19911991
RHD psiRHD*08N.01
RHD*Pseudogene
weak D type 4 clustercDeComplex changes609G>A
654G>C (M218I)
667T>G (F223V)
674C>T (S225F)
807T>G (Y269X)
IVS3-19 dupl 37
20002000
RHD(1080del10)RHD*01N.36Eurasian D clusternot reportedShort deletion1080del10
2010
RHD(1228-2del21)RHD*01N.44Eurasian D clusternot reportedShort deletionIVS9-2del21
2014
RHD(142delM)RHD*01N.74Eurasian D clusternot reportedIn frame deletion424delATG (142delM)
RHD(216dupCA,1195G>A)RHD*01N.45Eurasian D clusterCDeComplex changes1195G>A (A399T)
216dupCA
2012
RHD(297del23)RHD*01N.37Eurasian D clusternot reportedShort deletion297del23
2013
RHD(325delA)RHD*01N.11Eurasian D clusterCDeShort deletion325del A
20072007
RHD(330delGT)RHD*01N.35Eurasian D clusternot reportedShort deletion330delGT
20072007
RHD(343del C)RHD*01N.23Eurasian D clusterCDeShort deletion343del C
20042009
RHD(361del11)RHD*01N.41Eurasian D clusterCDeShort deletion361delTTGTCGGTGCT
20122012
RHD(449del T)RHD*01N.12Eurasian D clusterCDeShort deletion449del T
2004
RHD(489delAGAC)RHD*01N.13Eurasian D clusterCDeShort deletion487del ACAG
19981998
RHD(545delCTGT)RHD*01N.46Eurasian D clustercDeShort deletion545delCTGT
20122012
RHD(615delCA)RHD*01N.34Eurasian D clusterCDeShort deletion615delCA
20092012
RHD(652delA 653T>G)RHD*01N.17Eurasian D clusternot reportedSubstitution with frameshift652delA 653T>G
2006
RHD(660delG)RHD*01N.29
RHD*01N.78
Eurasian D clusterCDeShort deletion660delG
20082009
RHD(711del C)RHD*01N.16Eurasian D clusterCDeShort deletion711del C
20022002
RHD(712delG)RHD*01N.33Eurasian D clusterCDeShort deletion712delG
20082009
RHD(745del13)RHD*01N.47Eurasian D clusterCDeShort deletion745delGTGGTGACAGCCA
758TC>AG
2008
RHD(786del A)RHD*01EL.13
RHD*DEL13
Eurasian D clusterCDeShort deletion786del A
20042009
RHD(78delC)RHD*01N.32Eurasian D clusterCDeShort deletion78delC
20092010
RHD(822delG)RHD*01N.48Eurasian D clusternot reportedShort deletion822delG
2014
RHD(909ins TGGCT, IVS6+2del TAAG)RHD*01N.27Eurasian D clusterCDeComplex changes909ins TGGCT
IVS6+2del TAAG
20022002
RHD(915delC)RHD*01N.49Eurasian D clusternot reportedShort deletion915delC
20142014
RHD(93insT)RHD*01EL.18
RHD*DEL18
RHD*01N.50
Eurasian D clusterCDeShort insertion93insT
20082008
RHD(950delA)RHD*01N.51Eurasian D clusternot reportedShort deletion950delA
2012
RHD(970delCAC,976delTCCATCATGGGCTACA)RHD*01N.28Eurasian D clusterCDeShort deletion970delCAC
976delTCCATCATGGGCTACA
20082009
RHD(delEx1)RHD*01N.67Eurasian D clusternot reportedlarge deletiondelEx1
RHD(G212V)RHD*01N.15Eurasian D clusterCDeMissense (splice site affected)635G>T (G212V)
20012001
RHD(G308X)RHD*01EL.15
RHD*DEL15
RHD*01N.52
Eurasian D clusterCDeNonsense mutation922G>T (G308X)
2010
RHD(G314V)RHD*01N.20Eurasian D clusterCDeMissense (splice site affected)941G>T (G314V)
19971997
RHD(G336D)RHD*01N.80Eurasian D clusternot reportedSingle missense mutation1007G>A (G336D)
2011
RHD(G385D)RHD*01N.53Eurasian D clusternot reportedMissense (splice site affected)1154G>A (G385D)
20142014
RHD(IVS2+1G>A)RHD*01N.24Eurasian D clusternot reportedSplice site mutationIVS2+1G>A
20072007
RHD(IVS2-1G>A)RHD*01N.25Eurasian D clusterCDeSplice site mutationIVS2-1G>A
20052005
RHD(IVS3+1G>A)RHD*01EL.08
RHD*DEL8
Eurasian D clusterCDeSplice site mutationIVS3+1G>A
20012001
RHD(IVS3+2T>A)RHD*01EL.09
RHD*DEL9
Eurasian D clustercDESplice site mutationIVS3+2T>A
20082009
RHD(IVS4+1G>T,1136C>T)RHD*01N.69DAU clusternot reportedSplice site mutation1136C>T (T379M)
IVS4+1G>T
RHD(IVS5+1G>A)RHD*01N.54Eurasian D clusternot reportedSplice site mutationIVS5+1G>A
2012
RHD(IVS6+1G>A)RHD*01N.55Eurasian D clusterCDeSplice site mutationIVS6+1G>A
20142014
RHD(IVS6+2T>A)RHD*01N.38Eurasian D clusternot reportedSplice site mutationIVS6+2T>A
2013
RHD(IVS7+1G>T)RHD*01N.70Eurasian D clusternot reportedSplice site mutationIVS7+1G>T
RHD(IVS7+2T>C)RHD*01N.56Eurasian D clusternot reportedSplice site mutationIVS7+2T>C
2012
RHD(IVS8+1G>A)RHD*01N.26Eurasian D clusterCDeSplice site mutationIVS8+1G>A
20012001
RHD(L337R)RHD*01EL.38
RHD*DEL38
RHD*01N.57
Eurasian D clusterCDeSingle missense mutation1010T>G (L337R)
20142014
RHD(L386X)Eurasian D clusternot reportedSingle missense mutation1157T>A (L386X)
IVS5-41delCTCT
20142014
RHD(M218I, F223V, S225F,Y269X)weak D type 4 clusternot reportedComplex changes609G>A
654G>C (M218I)
667T>G (F223V)
674C>T (S225F)
807T>G (Y269X)
2009
RHD(Q200X)RHD*01N.59Eurasian D clusternot reportedNonsense mutation598C>T (Q200X)
2011
RHD(Q362X)RHD*01N.64Eurasian D clusternot reportedNonsense mutation1084C>T (Q362X)
RHD(Q405X)RHD*01N.60Eurasian D clusternot reportedNonsense mutation1213C>T (Q405X)
2015
RHD(Q41X)RHD*01N.09Eurasian D clusterCDeNonsense mutation121C>T (Q41X)
643T>C (F215L)
646T>C
988T>C (Y330H)
19971997
RHD(R318X)RHD*01N.61Eurasian D clusterCDeNonsense mutation952C>T (R318X)
20082009
RHD(S254X)RHD*01N.62Eurasian D clusterCDeNonsense mutation761C>G (S254X)
20152015
RHD(S256X)RHD*01N.39Eurasian D clusterCDeNonsense mutation767C>G (S256X)
20122013
RHD(S68T)-RHCe(3-9)-RHDRHD*01N.04Eurasian D clusterCDehybrid allele203G>C (S68T)
Hybrid RHCE(3-9)
20052005
RHD(T148R)RHD*01N.73Eurasian D clusternot reportedSingle missense mutation443C>G (T148R)
2012
RHD(V56M,W90X)Eurasian D clusterCDeNonsense mutation166G>A (V56M)
270G>A (W90X)
20082009
RHD(W16X)RHD*01N.08Eurasian D clusterCDeNonsense mutation48G>A (W16X)
20012001
RHD(W185X)RHD*01N.14Eurasian D clusterCDeNonsense mutation554G>A (W185X)
20052005
RHD(W90X)RHD*01N.10Eurasian D clusterCDeNonsense mutation270G>A (W90X)
20022002
RHD(Y269X)RHD*01N.18Eurasian D clusterCDeNonsense mutation807T>G (Y269X)
20042009
RHD(Y311X)[761G]RHD*01N.63Eurasian D clusternot reportedNonsense mutation933C>G (Y311X)
RHD(Y311X)[933A]RHD*01N.19Eurasian D clusterCDeNonsense mutation933C>A (Y311X)
20052005
RHD(Y330X)RHD*01N.21Eurasian D clusterCDeNonsense mutation990C>G (Y330X)
20012001
RHD(Y343X)RHD*01N.40Eurasian D clustercDENonsense mutation1029C>A (Y343X)
20122013
RHD(Y401X)RHD*01N.22
RHD*DEL17
RHD*01EL.17
Eurasian D clustercDENonsense mutation1203T>A (Y401X)
20042005
RHD*745_757delRHD*01N.30Eurasian D clusternot reportedShort deletion745delGTGGTGACAGCCA
RHD-RHCE(2-10)no RHDCdehybrid alleleHybrid RHCE(2-10)
20042004
RHD-RHCe(2-7)-RHDRHD*01N.05Eurasian D clusterCDehybrid alleleHybrid RHCE(3-7)
20012001
RHD-RHCe(2-9)-RHDRHD*01N.03Eurasian D clusterCDehybrid alleleHybrid RHCE(3-9)
19961996
RHD-RHCE(3)--weak D type 4.0RHD*01N.72weak D type 4 clusternot reportedhybrid allele602C>G (T201R)
667T>G (F223V)
819G>A
Hybrid RHCE(3)
RHD-RHCE(4-7)-RHDRHD*01N.07Eurasian D clustercDEhybrid alleleHybrid RHCE(4-7)
19961996
RHD-RHCE(4-7)-RHD1RHD*01N.07Eurasian D clustercDEhybrid alleleHybrid RHCE(4-7)
RHD-RHCE(4-7)-RHD2RHD*01N.07Eurasian D clustercDEhybrid alleleHybrid RHCE(4-7)
RHD-RHCE(4-8)-RHDRHD*01N.07Eurasian D clusterCDehybrid alleleHybrid RHCE(4-7)
20052005
RHD-RHCE(8-9)-RHDEurasian D clusterCDehybrid alleleHybrid RHCE(8-9)
19971997