Key changes from standard allele

1136C>T (T379M)

ISBT allele designation


Nucleotide changes relative to "standard RHD"

c.1136 C>T

Amino acid changes relative to standard protein

Thr to Met at codon 379


ISBT group

partial RHD

Phenotype characterization and grouping

D positive (apparently normal); Partial D

Haplotype (typical)


Allele cluster

DAU cluster


First full publication: 2002 Wagner FF et. al. Blood. 2002 Jul 1;100(1):306-11. (submitted 2002-01-31, released 2002-06-19)

Other relevant descriptions:
KU556685 (submitted 2016-01-15, released 2016-07-24)


Rhesus index 0.74 Wagner FF et. al. Blood. 2002 Jul 1;100(1):306-11.


Mali (general): Haplotype frequency 18% in Mali Wagner FF et. al. BMC Genet. 2003 Sep 24;4:14. Frequency 1:5
South-Western Germany: 3 of 194 random ccDee samples Wagner FF et. al. Blood. 2002 Jul 1;100(1):306-11. Frequency 1:3.843
Brazil (general): 2 of 369 samples with atypical D expression Arnoni CP et. al. Transfusion. 2014 Apr;54(4):962-9. doi: 10.1111/trf.12557. Epub 2014 Feb 28.
African American: SWiTCH trial Chou ST et. al. Blood Adv. 2017 Aug 3;1(18):1414-1422. doi: 10.1182/bloodadvances.2017007898. Frequency 1:0,102
French of African ancestry: 5 of 280 D pos donors with DAU-3 in trans Kappler-Gratias S et. al. Blood Transfus. 2014 Jan;12 Suppl 1:s264-72. doi: 10.2450/2013.0270-12. Epub 2013

Related Alleles

DAU-13 [RHD(W16C,T379M)]
DAU-0.1 [RHD(579G>A,1136C>T)]
DAU-1 [RHD(S230I,T379M)]
DAU-2 [RHD(R70Q,S333N,T379M)]
DAU-3 [RHD(V279M,T379M)]
DAU-4 [RHD(E233K,T379M)]
DAU-5 [RHD(F223V,E233Q,T379M)]
DAU-6 [RHD(S333N,T379M)]
DAU-7 [RHD(V279M,S333N,T379M)]
DAU-0.2 [RHD(150T>C,1136C>T)]
DAU-11 [RHD(A85V,V279M,T379M)]
DAU-9 [RHD(F179L,T379M)]
DAU-5.1 [RHD(F223V,E233Q,T379M)[1122C>T]]
RHD(G263L,T379M) [RHD(G263L,T379M)]
RHD(IVS4+1G>T,1136C>T) [RHD(IVS4+1G>T,1136C>T)]
DAU-12 [RHD(L181P,T379M)]
RHD(M1_S2insV,T379M) [RHD(M1_S2insV,T379M)]
RHD(M1V,T379M) [RHD(M1V,T379M)]
DAU-8 [RHD(R114W,T379M)[579G>A]]
RHD(S254L,T379M) [RHD(S254L,T379M)]
DAU-14 [RHD(S68N,T379M)[201G>A]]
DAU-10 [RHD(V247L,T379M)[579G>A]]

Additional comments

At AABB 2011, the allele was discussed as partial RHD. Peer-reviewed published reports of allo-anti-D immunization are lacking, however, despite its extreme high frequency in some populations..

Last update: 2018-04-23 (yyyy-MM-dd)