Key changes from standard allele

1136C>T (T379M)
667T>G (F223V)
697G>C (E233Q)

ISBT allele designation


Nucleotide changes relative to "standard RHD"

c.[667 T>G;697 G>C;1136 C>T]

Amino acid changes relative to standard protein

F223V, E233Q, T379M

ISBT group

partial RHD

Phenotype characterization and grouping

Partial D

Haplotype (typical)


Allele cluster

DAU cluster


First full publication: 2005 Chen Q & Flegel WA Transfusion. 2005 Jul;45(7):1183-91.


Antigen Dw positive Flegel WA et. al. Transfusion. 2008 Jan;48(1):25-33. Epub 2007 Sep 27.


Brazaville and Teke groups: Touinssi M et. al. Transfusion. 2009 Jul;49(7):1353-60.
Brazil (general): 1 of 369 samples with atypical D expression Arnoni CP et. al. Transfusion. 2014 Apr;54(4):962-9. doi: 10.1111/trf.12557. Epub 2014 Feb 28.
Canada (general): Denomme GA et. al. Transfusion. 2005 Oct;45(10):1554-60.
French of African ancestry: 1 of 280 D pos donors, in trans to RHD psi (in addition 1 heterozygous occurrence in trans to normal RHD and 1 in trans to weak D type 4.0) Kappler-Gratias S et. al. Blood Transfus. 2014 Jan;12 Suppl 1:s264-72. doi: 10.2450/2013.0270-12. Epub 2013
South-Western Germany: Chen Q & Flegel WA Transfusion. 2005 Jul;45(7):1183-91.

Related Alleles

DAU-5.1 [RHD(F223V,E233Q,T379M)[1122C>T]]

Additional comments

Last update: 2018-04-23 (yyyy-MM-dd)