Designation | ISBT name | Cluster | Haplotype | Mechanism | Alterations | First mention | Definitive publication |
Ccdes-1 | RHD*03N.01 | DIVa cluster | Ccde | Complex changes | 1006G>T (G336C) 186G>T (L62F) 410C>T (A137V) 455A>C (N152T) Hybrid RHCE[245V](4-7) | 2004 | 2004 |
Ccdes-2 | RHD*01N.06 | DIVa cluster | Ccde | hybrid allele | 1006G>T (G336C) Hybrid RHCE[245V](4-7) | 2009 | 2009 |
RHCE(1)-D(6)-CE(7-10) | RHD*01N.42 | no RHD | Cde | large deletion | 2002 | 2002 | |
RHCE(1-3)-RHD(4-10) | RHD*01N.43 | Eurasian D cluster | cDE | hybrid allele | Hybrid RHCE(1-3) | 2004 | 2009 |
RHCE(1-9)-RHD | RHD*01N.02 | Eurasian D cluster | cDE | hybrid allele | Hybrid RHCE(1-9) | 2001 | 2001 |
RHCE-D(3[361del11]-10) | Eurasian D cluster | not reported | Complex changes | 361delTTGTCGGTGCT Hybrid RHCE(1-2) | |||
RHD deletion | RHD*01N.01 | no RHD | cde | large deletion | RHD deletion | 1991 | 1991 |
RHD psi | RHD*08N.01 RHD*Pseudogene | weak D type 4 cluster | cDe | Complex changes | 609G>A 654G>C (M218I) 667T>G (F223V) 674C>T (S225F) 807T>G (Y269X) IVS3-19 dupl 37 | 2000 | 2000 |
RHD(1026C>T) | Eurasian D cluster | not reported | Silent mutation | 1026C>T (I342I) | 2015 | 2015 | |
RHD(1080del10) | RHD*01N.36 | Eurasian D cluster | not reported | Short deletion | 1080del10 | 2010 | |
RHD(1228-2del21) | RHD*01N.44 | Eurasian D cluster | not reported | Short deletion | IVS9-2del21 | 2014 | |
RHD(142delM) | RHD*01N.74 RHD*424_426delATG | Eurasian D cluster | not reported | In frame deletion | 424delATG (142delM) | ||
RHD(208delinsTG) | Eurasian D cluster | not reported | Short insertion | 208delinsTG | 2017 | ||
RHD(216dupCA,1195G>A) | RHD*01N.45 | Eurasian D cluster | CDe | Complex changes | 1195G>A (A399T) 216dupCA | 2012 | |
RHD(297del23) | RHD*01N.37 | Eurasian D cluster | not reported | Short deletion | 297del23 | 2013 | |
RHD(325delA) | RHD*01N.11 | Eurasian D cluster | CDe | Short deletion | 325del A | 2007 | 2007 |
RHD(330delGT) | RHD*01N.35 | Eurasian D cluster | not reported | Short deletion | 330delGT | 2007 | 2007 |
RHD(343del C) | RHD*01N.23 | Eurasian D cluster | CDe | Short deletion | 343del C | 2004 | 2009 |
RHD(361del11) | RHD*01N.41 | Eurasian D cluster | CDe | Short deletion | 361delTTGTCGGTGCT | 2014 | 2014 |
RHD(449del T) | RHD*01N.12 | Eurasian D cluster | CDe | Short deletion | 449del T | 2004 | |
RHD(489delAGAC) | RHD*01N.13 | Eurasian D cluster | CDe | Short deletion | 487del ACAG | 1998 | 1998 |
RHD(520G>A,1080_1989del) | Eurasian D cluster | CDe | Complex changes | 1080del10 520G>A (V174M) | 2014 | 2014 | |
RHD(545delCTGT) | RHD*01N.46 | Eurasian D cluster | cDe | Short deletion | 545delCTGT | 2012 | 2012 |
RHD(615delCA) | RHD*01N.34 | Eurasian D cluster | CDe | Short deletion | 615delCA | 2009 | 2012 |
RHD(652delA 653T>G) | RHD*01N.17 | Eurasian D cluster | not reported | Substitution with frameshift | 652delA 653T>G | 2006 | |
RHD(660delG) | RHD*01N.29 RHD*660delG RHD*01N.78 | Eurasian D cluster | CDe | Short deletion | 660delG | 2008 | 2009 |
RHD(697delG) | RHD*01N.82 RHD*697delG | Eurasian D cluster | not reported | Short deletion | 697delG | ||
RHD(702delG) | RHD*01N.83 RHD*702delG | Eurasian D cluster | not reported | Short deletion | 702delG | 2017 | |
RHD(711del C) | RHD*01N.16 | Eurasian D cluster | cDE | Short deletion | 711del C | 2002 | 2002 |
RHD(712delG) | RHD*01N.33 | Eurasian D cluster | CDe | Short deletion | 712delG | 2008 | 2009 |
RHD(745del13) | RHD*01N.47 | Eurasian D cluster | CDe | Short deletion | 745delGTGGTGACAGCCA 758TC>AG | 2008 | |
RHD(786del A) | RHD*01EL.13 RHD*DEL13 | Eurasian D cluster | CDe | Short deletion | 786del A | 2004 | 2009 |
RHD(78delC) | RHD*01N.32 | Eurasian D cluster | CDe | Short deletion | 78delC | 2009 | 2010 |
RHD(822delG) | RHD*01N.48 | Eurasian D cluster | not reported | Short deletion | 822delG | 2014 | |
RHD(909ins TGGCT, IVS6+2del TAAG) | RHD*01N.27 | Eurasian D cluster | CDe | Complex changes | 909ins TGGCT IVS6+2del TAAG | 2002 | 2002 |
RHD(915delC) | RHD*01N.49 | Eurasian D cluster | not reported | Short deletion | 915delC | 2014 | 2014 |
RHD(93insT) | RHD*01EL.18 RHD*DEL18 RHD*01N.50 | Eurasian D cluster | CDe | Short insertion | 93insT | 2008 | 2008 |
RHD(950delA) | RHD*01N.51 | Eurasian D cluster | not reported | Short deletion | 950delA | 2012 | |
RHD(970delCAC,976delTCCATCATGGGCTACA) | RHD*01N.28 | Eurasian D cluster | CDe | Short deletion | 970delCAC 976delTCCATCATGGGCTACA | 2008 | 2009 |
RHD(delEx1) | RHD*01N.67 | Eurasian D cluster | not reported | large deletion | delEx1 | ||
RHD(G212V) | RHD*01N.15 | Eurasian D cluster | CDe | Missense (splice site affected) | 635G>T (G212V) | 2001 | 2001 |
RHD(G308X) | RHD*01EL.15 RHD*DEL15 RHD*01N.52 | Eurasian D cluster | CDe | Nonsense mutation | 922G>T (G308X) | 2010 | |
RHD(G314V) | RHD*01N.20 | Eurasian D cluster | CDe | Missense (splice site affected) | 941G>T (G314V) | 1997 | 1997 |
RHD(G336D) | RHD*01N.80 RHD*1007A | Eurasian D cluster | not reported | Single missense mutation | 1007G>A (G336D) | 2011 | |
RHD(G385D) | RHD*01N.53 | Eurasian D cluster | not reported | Missense (splice site affected) | 1154G>A (G385D) | 2014 | 2014 |
RHD(IVS2+1G>A) | RHD*01N.24 | Eurasian D cluster | not reported | Splice site mutation | IVS2+1G>A | 2007 | 2007 |
RHD(IVS2-1G>A) | RHD*01N.25 | Eurasian D cluster | CDe | Splice site mutation | IVS2-1G>A | 2005 | 2005 |
RHD(IVS3+1G>A) | RHD*01EL.08 RHD*DEL8 | Eurasian D cluster | CDe | Splice site mutation | IVS3+1G>A | 2001 | 2001 |
RHD(IVS3+2T>A) | RHD*01EL.09 RHD*DEL9 | Eurasian D cluster | cDE | Splice site mutation | IVS3+2T>A | 2008 | 2009 |
RHD(IVS4+1G>T,1136C>T) | RHD*01N.69 | DAU cluster | not reported | Splice site mutation | 1136C>T (T379M) IVS4+1G>T | ||
RHD(IVS5+1G>A) | RHD*01N.54 | Eurasian D cluster | not reported | Splice site mutation | IVS5+1G>A | 2012 | |
RHD(IVS6+1G>A) | RHD*01N.55 | Eurasian D cluster | CDe | Splice site mutation | IVS6+1G>A | 2014 | 2014 |
RHD(IVS6+2T>A) | RHD*01N.38 | Eurasian D cluster | not reported | Splice site mutation | IVS6+2T>A | 2013 | |
RHD(IVS7+1G>T) | RHD*01N.70 | Eurasian D cluster | not reported | Splice site mutation | IVS7+1G>T | ||
RHD(IVS7+2T>C) | RHD*01N.56 | Eurasian D cluster | not reported | Splice site mutation | IVS7+2T>C | 2012 | |
RHD(IVS8+1G>A) | RHD*01N.26 | Eurasian D cluster | CDe | Splice site mutation | IVS8+1G>A | 2001 | 2001 |
RHD(L337R) | RHD*01EL.38 RHD*DEL38 RHD*01N.57 | Eurasian D cluster | CDe | Single missense mutation | 1010T>G (L337R) | 2014 | 2014 |
RHD(L386X) | Eurasian D cluster | not reported | Single missense mutation | 1157T>A (L386X) IVS5-41delCTCT | 2014 | 2014 | |
RHD(M218I, F223V, S225F,Y269X) | weak D type 4 cluster | not reported | Complex changes | 609G>A 654G>C (M218I) 667T>G (F223V) 674C>T (S225F) 807T>G (Y269X) | 2009 | ||
RHD(Q200X) | RHD*01N.59 | Eurasian D cluster | not reported | Nonsense mutation | 598C>T (Q200X) | 2011 | |
RHD(Q362X) | RHD*01N.64 | Eurasian D cluster | not reported | Nonsense mutation | 1084C>T (Q362X) | ||
RHD(Q405X) | RHD*01N.60 | Eurasian D cluster | not reported | Nonsense mutation | 1213C>T (Q405X) | 2015 | |
RHD(Q41X) | RHD*01N.09 | Eurasian D cluster | CDe | Nonsense mutation | 121C>T (Q41X) 643T>C (F215L) 646T>C 988T>C (Y330H) | 1997 | 1997 |
RHD(R318X) | RHD*01N.61 | Eurasian D cluster | CDe | Nonsense mutation | 952C>T (R318X) | 2008 | 2009 |
RHD(S254X) | RHD*01N.62 | Eurasian D cluster | CDe | Nonsense mutation | 761C>G (S254X) | 2015 | 2015 |
RHD(S256X) | RHD*01N.39 | Eurasian D cluster | CDe | Nonsense mutation | 767C>G (S256X) | 2012 | 2013 |
RHD(S68T)-RHCe(3-9)-RHD | RHD*01N.04 | Eurasian D cluster | CDe | hybrid allele | 203G>C (S68T) Hybrid RHCE(3-9) | 2005 | 2005 |
RHD(T148R) | RHD*01N.73 RHD*443G | Eurasian D cluster | not reported | Single missense mutation | 443C>G (T148R) | 2012 | 2012 |
RHD(V56M,W90X) | Eurasian D cluster | CDe | Nonsense mutation | 166G>A (V56M) 270G>A (W90X) | 2008 | 2009 | |
RHD(W16X) | RHD*01N.08 | Eurasian D cluster | CDe | Nonsense mutation | 48G>A (W16X) | 2001 | 2001 |
RHD(W185X) | RHD*01N.14 | Eurasian D cluster | CDe | Nonsense mutation | 554G>A (W185X) | 2005 | 2005 |
RHD(W185X) [c,555G>A] | Eurasian D cluster | not reported | Nonsense mutation | 555G>A (W185X) | 2015 | 2015 | |
RHD(W90X) | RHD*01N.10 | Eurasian D cluster | CDe | Nonsense mutation | 270G>A (W90X) | 2002 | 2002 |
RHD(Y269X) | RHD*01N.18 | Eurasian D cluster | CDe | Nonsense mutation | 807T>G (Y269X) | 2004 | 2009 |
RHD(Y311X)[761G] | RHD*01N.63 | Eurasian D cluster | not reported | Nonsense mutation | 933C>G (Y311X) | ||
RHD(Y311X)[933A] | RHD*01N.19 | Eurasian D cluster | CDe | Nonsense mutation | 933C>A (Y311X) | 2005 | 2005 |
RHD(Y330X) | RHD*01N.21 | Eurasian D cluster | CDe | Nonsense mutation | 990C>G (Y330X) | 2001 | 2001 |
RHD(Y343X) | RHD*01N.40 | Eurasian D cluster | cDE | Nonsense mutation | 1029C>A (Y343X) | 2012 | 2013 |
RHD(Y401X) | RHD*01N.22 RHD*DEL17 RHD*01EL.17 | Eurasian D cluster | cDE | Nonsense mutation | 1203T>A (Y401X) | 2004 | 2005 |
RHD*745_757del | RHD*01N.30 | Eurasian D cluster | not reported | Short deletion | 745delGTGGTGACAGCCA | ||
RHD-RHCE(2-10) | no RHD | Cde | hybrid allele | Hybrid RHCE(2-10) | 2004 | 2004 | |
RHD-RHCe(2-7)-RHD | RHD*01N.05 | Eurasian D cluster | CDe | hybrid allele | Hybrid RHCE(3-7) | 2001 | 2001 |
RHD-RHCe(2-9)-RHD | RHD*01N.03 | Eurasian D cluster | CDe | hybrid allele | Hybrid RHCE(3-9) | 1996 | 1996 |
RHD-RHCE(3)--weak D type 4.0 | RHD*01N.72 | weak D type 4 cluster | not reported | hybrid allele | 602C>G (T201R) 667T>G (F223V) 819G>A Hybrid RHCE(3) | ||
RHD-RHCE(4-7)-RHD | RHD*01N.07 | Eurasian D cluster | cDE | hybrid allele | Hybrid RHCE(4-7) | 1996 | 1996 |
RHD-RHCE(4-7)-RHD1 | RHD*01N.07 | Eurasian D cluster | cDE | hybrid allele | Hybrid RHCE(4-7) | ||
RHD-RHCE(4-7)-RHD2 | RHD*01N.07 | Eurasian D cluster | cDE | hybrid allele | Hybrid RHCE(4-7) | ||
RHD-RHCE(4-8)-RHD | RHD*01N.07 | Eurasian D cluster | CDe | hybrid allele | Hybrid RHCE(4-7) | 2005 | 2005 |
RHD-RHCE(8-9)-RHD | Eurasian D cluster | CDe | hybrid allele | Hybrid RHCE(8-9) | 1997 | 1997 | |
RHDex10del type 2 | Eurasian D cluster | not reported | large deletion | del1227-2108_1254+1317 | 2017 | 2017 |