DIV type 1.0

Structure

RHD(L62F,A137V,N152T,D350H)

Key changes from standard allele

1048G>C (D350H)
186G>T (L62F)
410C>T (A137V)
455A>C (N152T)

ISBT allele designation

RHD*04.01
RHD*DIVa.

Nucleotide changes relative to "standard RHD"

c.[186 G>T;410 C>T;455 A>C;1048 G>C]

Amino acid changes relative to standard protein

L62F, A137V, N152T, D350H

Haplotype (typical)

cDe

Allele cluster

DIVa cluster

Descriptions

First submission to GenBank: 2012 HF549086 (submitted 2012-11-06, released 2012-12-04)

ISBT group

partial RHD

Phenotype characterization and grouping

Partial D; D category

Serology

anti-D observed (2 cases) von Zabern I et. al. Transfusion. 2013 Nov;53(11 Suppl 2):2960-73. doi: 10.1111

Observations

African ancestry (general): von Zabern I et. al. Transfusion. 2013 Nov;53(11 Suppl 2):2960-73. doi: 10.1111
Brazaville and Teke groups: Touinssi M et. al. Transfusion. 2009 Jul;49(7):1353-60.
Brazil (general): 1 of 369 samples with atypical D expression Arnoni CP et. al. Transfusion. 2014 Apr;54(4):962-9. doi: 10.1111/trf.12557. Epub 2014 Feb 28.

Additional comments

This structure was established for DIVa-like samples analysed in Ulm by FFW. It differes from the original DIVa structure by the additional A137V substitution and is currently believed to represent the correct "DIVa structure". In 2013, von Zabern suggested the designation DIV type 1.0. This designation is used here in the RhesusBase, because the ISBT name "DIVa" was historically used for several different molecular structures.

Last update: 2018-02-19 (yyyy-MM-dd)