weak D type 74



Key changes from standard allele

203G>C (S68T)

ISBT allele designation

RHD* 01W.74
RHD*weak D type 74

Nucleotide changes relative to "standard RHD"

c.203 G>C

Amino acid changes relative to standard protein

Ser to Thr at codon 68


ISBT group

weak D

Phenotype characterization and grouping

weak D type; weakened D expression

Haplotype (typical)

not reported

Allele cluster

Eurasian D cluster


First submission to GenBank: 2009 FN594775 (submitted 2009-09-19, released 2009-11-23)


No data


Linz region: FN594775

Related Alleles

RHD(S68T)-RHCe(3-9)-RHD [RHD(S68T)-RHCE(3-9)-RHD]

Additional comments

Haplotype CDe or cDe.
The designation weak D type 74 was documented and in use since 2009. Two years later, ISBT proposed to use the identical designation for the RHD-RHCE(2)-RHD allele. Hoping that ISBT will consider historical priority for numbering and change its numbering in the upcoming official nomenclature, the designation weak D type 74 is retained.

Last update: 2017-02-12 (yyyy-MM-dd)