weak D type 25



Key changes from standard allele

341G>A (R114Q)

ISBT allele designation

RHD*weak D type 25

Nucleotide changes relative to "standard RHD"

c.341 G>A

Amino acid changes relative to standard protein

Arg to Gln at codon 114


ISBT group

weak D

Phenotype characterization and grouping

weak D type; weakened D expression

Phenotypes observed

cDEe (major)

Haplotype (typical)

not reported

Allele cluster

Eurasian D cluster


First submission to GenBank: 2005 AJ548430 (submitted 2003-02-25, released 2005-02-26)

Other relevant descriptions:
Intron polymorphisms JX495049 (submitted 2012-08-15, released 2012-10-23)


Negative for JAL and JAHK Schmid P et. al. Transfusion. 2010 Jan;50(1):267-9.


India (general): 2 of 223 weak D samples Fichou Y et. al. Transfusion. 2018 Feb 25. doi: 10.1111/trf.14552.
Xian: 1 of 2493 samples D negative in saline Ye SH et. al. Blood Transfus. 2014 Jul;12(3):396-404. doi: 10.2450/2013.0121-13. Epub 2013 Dec

Related Alleles

RHD(R114Q,A399T) [RHD(R114Q,A399T)]

Additional comments

Last update: 2018-05-23 (yyyy-MM-dd)