weak D type 18

Structure

RHD(R7W)

Key changes from standard allele

19C>T (R7W)

ISBT allele designation

RHD*01W.18
RHD*weak D type 18

Nucleotide changes relative to "standard RHD"

c.19 C>T

Amino acid changes relative to standard protein

Arg to Trp at codon 7

R7W

ISBT group

weak D

Phenotype characterization and grouping

weak D type; weakened D expression

Haplotype (typical)

not reported

Allele cluster

Eurasian D cluster

Descriptions

First submission to GenBank: 2000 CAB75731 (submitted 2000-02-17, released 2000-02-22)

Other relevant descriptions:
AJ287290
KP718114 (submitted 2015-01-28, released 2015-07-25)
KU195715 (submitted 2015-11-25, released 2016-09-04)

Serology

weak D AJ287290
weak D variant KP718114

Observations

Brazil (general): 1 of 369 samples with atypical D expression Arnoni CP et. al. Transfusion. 2014 Apr;54(4):962-9. doi: 10.1111/trf.12557. Epub 2014 Feb 28.
China (general): KP718114
Germany (general): Doescher A & Wagner FF published on RhesusBase NOTE_3

Additional comments

Last update: 2018-02-19 (yyyy-MM-dd)