weak D type 15

Structure

RHD(G282D)

Key changes from standard allele

845G>A (G282D)

ISBT allele designation

RHD*15
RHD*weak partial 15

Nucleotide changes relative to "standard RHD"

c.845 G>A

Amino acid changes relative to standard protein

Gly to Asp at codon 282

G282D

ISBT group

partial RHD

Phenotype characterization and grouping

weak D type; weakened D expression; Partial D

Phenotypes observed

cDEe (major)
CcDEe (to confirm)
cDE (to confirm)
CDEe (to confirm)
CcDe (to confirm)

Haplotype (typical)

cDE

Allele cluster

Eurasian D cluster

Descriptions

First full publication: 1999 Wagner FF et. al. Blood. 1999 Jan 1;93(1):385-93.

Serology

Wagner FF et. al. Blood. 2000 Apr 15;95(8):2699-708.: anti-D (low titer)
weak D expression: direct agglutination negative, IAT 1+ to 3+ Ogasawara K et. al. Vox Sang. 2015 Sep 4. doi: 10.1111/vox.12322.

Observations

China (general): 13 of 32 samples with weak D phenotype He J et. al. Transfusion. 2015 Jan;55(1):137-43. doi: 10.1111/trf.12797. Epub 2014 Jul 29.
Japan (general): 12 of 45 samples with weak D expression Ogasawara K et. al. Vox Sang. 2015 Sep 4. doi: 10.1111/vox.12322.
Poland (general): population frequency 1:2600 Orzinska A et. al. Transfusion. 2013 Nov;53(11 Suppl 2):2945-53. doi: 10.1111
Taiwan: 4 of 7 weak D Lin IL et. al. Ann Hematol. 2003 Oct;82(10):617-20.
Xian: 62 of 2493 samples D negative in saline Ye SH et. al. Blood Transfus. 2014 Jul;12(3):396-404. doi: 10.2450/2013.0121-13. Epub 2013 Dec
Croatia (general): Dogic V et. al. Transfus Med. 2011 Aug;21(4):278-9.
South-Western Germany: Wagner FF et. al. Blood. 1999 Jan 1;93(1):385-93.

Additional comments

Last update: 2018-05-23 (yyyy-MM-dd)