RHD-RHCE(10)

Structure

RHD-RHCE(10)

Key changes from standard allele

hybrid RHCE(10)

ISBT allele designation

No designation assigned

Nucleotide changes relative to "standard RHD"

Amino acid changes relative to standard protein

ISBT group

Phenotype characterization and grouping

DEL

Haplotype (typical)

CDe

Allele cluster

Eurasian D cluster

Descriptions

First full publication: 2009 Li Q et. al. Vox Sang. 2009 Aug;97(2):139-46. Epub 2009 Mar 30.

Serology

Silvy M et. al. Transfusion. 2012 Feb 10.

Observations

France (general): 3 samples Silvy M et. al. Transfusion. 2012 Feb 10.
China (general): Li Q et. al. Vox Sang. 2009 Aug;97(2):139-46. Epub 2009 Mar 30.
Poland (general): Orzinska A et. al. Transfusion. 2013 Nov;53(11 Suppl 2):2945-53. doi: 10.1111

Related Alleles

RHD(745del13) [RHD(745delGTGGTGACAGCCA,758TC>AG)]

Additional comments

The sequence of the RHD exons was verified by sequencing. The cause of the DEL phenotype despite a normal coding sequence is unknown.
Suspiciously, recently an allele with a deletion of RHD exon 10 has been described that would yield the described PCR pattern and explain the weakening of D antigen. Hence, this allele might be obsolete.

Last update: 2012-03-28 (yyyy-MM-dd)