RHD(-115A>C)

Structure

RHD(-115A>C)

Key changes from standard allele

-115A>C

ISBT allele designation

No designation assigned

Nucleotide changes relative to "standard RHD"

c.-115 A>C

Amino acid changes relative to standard protein

ISBT group

Phenotype characterization and grouping

weakened D expression

Phenotypes observed

CcDe (major)

Haplotype (typical)

not reported

Allele cluster

Eurasian D cluster

Descriptions

Other relevant descriptions:
Fennell K et. al. Transfusion. 2017 Nov;57(11):2804-2808. doi: 10.1111/trf.14299. Epub 2017 Aug 16.

Serology

Mixed field pattern Fennell K et. al. Transfusion. 2017 Nov;57(11):2804-2808. doi: 10.1111/trf.14299. Epub 2017 Aug 16.

Observations

Canada (general): Fennell K et. al. Transfusion. 2017 Nov;57(11):2804-2808. doi: 10.1111/trf.14299. Epub 2017 Aug 16.

Additional comments

The mutation destroys an GATA motif -115 to -110 in the RHD promoter

Last update: 2018-12-02 (yyyy-MM-dd)