DVI type 2

Structure

RHD-RHCE(4-6)-RHD

Key changes from standard allele

Hybrid RHCE(4-6)

ISBT allele designation

RHD*06.02
RHD*DVI.2

Nucleotide changes relative to "standard RHD"

c.[505 A>C;509 T>G;514 A>T;544 T>A;577 G>A;594 A>T;602 C>G;667 T>G;697 G>C;712 G>A;733 G>C;744 C>T;787 G>A;800 A>T;916 G>A;932 A>G]

Amino acid changes relative to standard protein

M169L, M170R, I172F, S182T, E193K, K198N, T201R, F223V, E233Q, V238M, V245L, G263R, K267M, V306I, Y311C

ISBT group

partial RHD

Phenotype characterization and grouping

Partial D; D category; BARC positive

Haplotype (typical)

CDe

Allele cluster

Eurasian D cluster

Descriptions

First full publication: 1994 Mouro I et. al. Blood. 1994 Feb 15;83(4):1129-35.

Other relevant descriptions:
Breakpoint region Matassi G et. al. Am J Hum Genet. 1997 Apr;60(4):808-17.

Serology

Lacks epitopes 1,2,4,5,6,8 (9 epitope model) Wagner FF et. al. Blood. 1998 Mar 15;91(6):2157-68.

Observations

France (general): Most frequent DVI allele in France Mouro I et. al. Blood. 1994 Feb 15;83(4):1129-35.
Linz region: 8/201 samples with weak D expression Polin H et. al. Transfusion. 2007 Aug;47(8):1350-5.
South-Western Germany: Most frequent DVI allele in Germany Wagner FF et. al. Blood. 1998 Mar 15;91(6):2157-68.
China (general): 2 of 32 samples with variant D phenotype He J et. al. Transfusion. 2015 Jan;55(1):137-43. doi: 10.1111/trf.12797. Epub 2014 Jul 29.

Related Alleles

RHD(A137V,N152T)-CE(4-6)-D(7-10) [RHD(A137V,N152T)-CE(4-6)-D(7-10)]
DVI type 3 [RHD-RHCE(3-6)-RHD]
DVI type 3.2 [RHD-RHCE(3-6)-RHD(A399T)]
RHCE(1-9)-RHD [RHCE(1-9)-RHD]
RHD-RHCE(2-10) [RHD-RHCE(2-10)]
RHD-RHCe(2-7)-RHD [RHD-RHCE(3-7)-RHD]
RHD(L110P)-CE(3-9)-D [RHD(L110P)-CE(3-9)-D]
RHD(S68T)-RHCe(3-9)-RHD [RHD(S68T)-RHCE(3-9)-RHD]
RHD-RHCe(2-9)-RHD [RHD-RHCe(2-9)-RHD]
RHD-RHCe(2-9)-RHD1 [RHD-RHCE(3-9)-RHD]
RHD-RHCe(2-9)-RHD2 [RHD-RHCE(3-9)-RHD]
RHD-RHCE(4-7)-RHD [RHD-RHCE(4-7)-RHD]
RHD-RHCE(4-7)-RHD1 [RHD-RHCE(4-7)-RHD]
RHD-RHCE(4-7)-RHD2 [RHD-RHCE(4-7)-RHD]
RHD-RHCE(4-8)-RHD [RHD-RHCE(4-7)-RHD]
RHD-RHCE(4-9)-RHD [RHD-RHCE(4-9)-RHD]

Additional comments

This allele was the first partial D allele the structure of which was elucidated.

Last update: 2018-05-23 (yyyy-MM-dd)