DOL-1

Structure

RHD(M170T,F223V)

Key changes from standard allele

509T>C (M170T)
667T>G (F223V)

ISBT allele designation

RHD*12.01
RHD*DOL1

Nucleotide changes relative to "standard RHD"

c.[509 T>C;667 T>G]

Amino acid changes relative to standard protein

M170T, F223V

ISBT group

partial RHD

Phenotype characterization and grouping

Partial D

Haplotype (typical)

cDe

Usually linked to ceBI

Allele cluster

weak D type 4 cluster

Descriptions

First mention in abstract form: 1999 Avent ND & et al. Transfus. Med. 9(suppl) 33, 1999

First submission to GenBank: 2008 FM201788 (submitted 2008-07-11, released 2008-10-01)

First full publication: 2009 Flegel WA et. al. Transfusion. 2009 Jun;49(6):1059-69. Epub 2009 Feb 25.

Other relevant descriptions:
DOL-1 is linked to ceBI Roussel M et. al. Transfusion. 2012 Jun 13. aheadofprint

Serology

Partial D Flegel WA et. al. Transfusion. 2009 Jun;49(6):1059-69. Epub 2009 Feb 25.

Observations

African ancestry (general): Roussel M et. al. Transfusion. 2012 Jun 13. aheadofprint

Related Alleles

D-SPM [RHD(L62F,A137V,N152T,M170T,F223V)]
DIV-DOL [RHD(L62F,A137V,N152T,M170T,F223V)]
DOL-2 [RHD(M170T,F223V,L378V)]
DOL-3 [RHD(A137V,M170T,F223V)]
DOL-4 []

Additional comments

Last update: 2012-06-18 (yyyy-MM-dd)