DIV type 1.0



Key changes from standard allele

1048G>C (D350H)
186G>T (L62F)
410C>T (A137V)
455A>C (N152T)

ISBT allele designation


Nucleotide changes relative to "standard RHD"

c.[186 G>T;410 C>T;455 A>C;1048 G>C]

Amino acid changes relative to standard protein

L62F, A137V, N152T, D350H

ISBT group

partial RHD

Phenotype characterization and grouping

Partial D; D category

Haplotype (typical)


Allele cluster

DIVa cluster


First submission to GenBank: 2012 HF549086 (submitted 2012-11-06, released 2012-12-04)


anti-D observed (2 cases) von Zabern I et. al. Transfusion. 2013 Nov;53(11 Suppl 2):2960-73. doi: 10.1111


African ancestry (general): von Zabern I et. al. Transfusion. 2013 Nov;53(11 Suppl 2):2960-73. doi: 10.1111
Brazaville and Teke groups: Touinssi M et. al. Transfusion. 2009 Jul;49(7):1353-60.
Brazil (general): 1 of 369 samples with atypical D expression Arnoni CP et. al. Transfusion. 2014 Apr;54(4):962-9. doi: 10.1111/trf.12557. Epub 2014 Feb 28.
French of African ancestry: 2 of 280 D pos donors, in addition 2 alleles in heterozygous state; linked to RHCE*ceTI in five donors and RHCE*ce in one donor Kappler-Gratias S et. al. Blood Transfus. 2014 Jan;12 Suppl 1:s264-72. doi: 10.2450/2013.0270-12. Epub 2013

Related Alleles

Ccdes-1 [RHD(L62F,A137V,N152T)-RHCE(4-7)-RHD(G336C)]
DIVa-like [RHD(L62F,A137V,N152T,F223V,D350H)]

Additional comments

This structure was established for DIVa-like samples analysed in Ulm by FFW. It differes from the original DIVa structure by the additional A137V substitution and is currently believed to represent the correct "DIVa structure". In 2013, von Zabern suggested the designation DIV type 1.0. This designation is used here in the RhesusBase, because the ISBT name "DIVa" was historically used for several different molecular structures.

Last update: 2018-04-23 (yyyy-MM-dd)