DIII type 7

Structure

RHD-RHCE(2)-RHD(A137V,N152T,T201R,F223V)

Key changes from standard allele

410C>T (A137V)
455A>C (N152T)
602C>G (T201R)
667T>G (F223V)
819G>A
Hybrid RHCE(2)

ISBT allele designation

RHD*03.07
RHD*DIII.07

Nucleotide changes relative to "standard RHD"

c.[150 T>C;178 A>C;201 G>A;203 G>A;307 T>C;410 C>T;455 A>C;602 C>G;667 T>G;819 G>A]

Amino acid changes relative to standard protein

, I60L, S68N, S103P, A137V, N152T, T201R, F223V, A273A

ISBT group

partial RHD

Phenotype characterization and grouping

Partial D; D category

Haplotype (typical)

cDe

Allele cluster

DIVa cluster

Descriptions

First mention in abstract form: 2005 Tax MGHM Rh variability in multi-ethnic perspective (thesis)

First full publication: 2006 Grootkerk-Tax MG et. al. Transfusion. 2006 Apr;46(4):606-15.

Other relevant descriptions:
DIII type 7 is likely the structure present in the original DIIIb samples Lomas-Francis C et. al. Transfusion. 2012 Jan;52(1):39-42. (released 2011-07-13)
JF436967 (submitted 2011-02-28, released 2011-07-24)

Serology

Antigen DAK pos. Does not react with anti-D made by people with the DIII phenotype Lomas-Francis C et. al. Transfusion. 2012 Jan;52(1):39-42.

Observations

South Africa (general): Lomas-Francis C et. al. Transfusion. 2012 Jan;52(1):39-42.

Additional comments

This structure is underlying the samples initially serologically grouped as DIIIb. Lateron, other samples with DIIIb-like phenotype were shown to carry a different sttructure, and for many years DIIIb was used synonymous for (RHD-RHCE(2)-RHD) for many years (see DIIIb). In order to avoid confusion, the designation DIII type 7 was retained for this allele even when it became obvious that it represented the historical correct "DIIIb" structure.

Last update: 2017-01-28 (yyyy-MM-dd)