DHK

Structure

RHD(E233K)

Key changes from standard allele

697G>A (E233K)

ISBT allele designation

RHD*05.05
RHD*DV.5

Nucleotide changes relative to "standard RHD"

c.697 G>A

Amino acid changes relative to standard protein

Glu to Lys at codon 233

E233K

ISBT group

partial RHD

Phenotype characterization and grouping

Partial D

Phenotypes observed

CcDe (major)

Haplotype (typical)

CDe

Allele cluster

Eurasian D cluster

Descriptions

First submission to GenBank: 1998 AB012659 (submitted 1998-03-30, released 1998-09-08)

First full publication: 1999 Omi T et. al. Biochem Biophys Res Commun. 1999 Jan 27;254(3):786-94.

Other relevant descriptions:
Independent description as DYO Hyodo H et. al. Vox Sang. 2000;78(2):122-5.
DYO AB018969 (submitted 1998-10-20, released 1999-06-06)

Serology

The phenotype is distinct from DV and negative for Dw (Rh23) Omi T et. al. Transfusion. 2000 Feb;40(2):256-8.

Observations

China (general): GU724516
Japan (general): Hyodo H et. al. Vox Sang. 2000;78(2):122-5.
Japan (general): Omi T et. al. Biochem Biophys Res Commun. 1999 Jan 27;254(3):786-94.
Linz region: Polin H et. al. Transfusion. 2007 Aug;47(8):1350-5.
Xian: 1 of 2493 samples D negative in saline Ye SH et. al. Blood Transfus. 2014 Jul;12(3):396-404. doi: 10.2450/2013.0121-13. Epub 2013 Dec

Related Alleles

DAU-4 [RHD(E233K,T379M)]

Additional comments

The ISBT nomenclature is surprising: This allele shares neither phenotype nor molecular structure with D category V

Last update: 2019-11-13 (yyyy-MM-dd)