FUT1(R220C)

Structure

FUT1(R220C)

Key changes from standard allele

658C>T (Arg220Cys)

ISBT allele designation

FUT1*01W.09

Nucleotide changes relative to "standard FUT1"

c.658 C>T

Amino acid changes relative to standard protein

Ala to at codon rg220Cy

Arg220Cys

ISBT group

weak FUT1 activity

Phenotype characterization and grouping

Para-Bombay

Descriptions

First full publication: 1997 Yu LC et. al. Vox Sang. 1997;72(1):36-40. doi: 10.1046/j.1423-0410.1997.00036.x.

Other relevant descriptions:
Liang W et. al. Iran J Public Health. 2018 Aug;47(8):1128-1136.

Serology

Para-Bombay Liang W et. al. Iran J Public Health. 2018 Aug;47(8):1128-1136.
Para-Bombay Yu LC et. al. Vox Sang. 1997;72(1):36-40. doi: 10.1046/j.1423-0410.1997.00036.x.

Observations

China (general): Liang W et. al. Iran J Public Health. 2018 Aug;47(8):1128-1136.
China (general): 3 of 20 alleles in Chinese Para-Bombay Guo ZH et. al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2004 Oct;21(5):417-21.
China (general): 2 alleles present among 4 alleles in 2 Chinese Para-Bombay He YM et. al. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2007 Jun;15(3):626-9.
China (general): Very frequent among Lahu Chinese: 7 para-Bombay among 324 individuals tested; 4 (6?) of 14 alleles Cai XH et. al. Transfus Med. 2011 Jun;21(3):209-10. doi: 10.1111/j.1365-3148.2010.01066.x. Epub
China (general): 3 of 34 alleles in 17 Chinese para-Bombay Cai XH et. al. Blood Transfus. 2011 Oct;9(4):466-8. doi: 10.2450/2011.0115-10. Epub 2011 Jun 15.
China (general): 6 of 18 alleles in 9 para-Bombay in Guangdong. Usually associated with Se357. Luo G et. al. Transfusion. 2013 Dec;53(12):3224-9. doi: 10.1111/trf.12183. Epub 2013 Apr 8.
Taiwan: Yu LC et. al. Vox Sang. 1997;72(1):36-40. doi: 10.1046/j.1423-0410.1997.00036.x.
Taiwan: 3 of 60 alleles in Taiwanese Para-Bombay Chen DP et. al. Ann Clin Lab Sci. 2004 Summer;34(3):314-8.

Related Alleles

FUT1(A12V,R220C) [FUT1(A12V,R220C)]

Additional comments

Usually associanted with Se357

Last update: 2020-03-17 (yyyy-MM-dd)