standard RHD



Key changes from standard allele

ISBT allele designation


Nucleotide changes relative to "standard RHD"

None reported

Amino acid changes relative to standard protein

Haplotype (typical)


Allele cluster

Eurasian D cluster


Other relevant descriptions:
The 1036 T>C of this sequence is usually not found in RHD and most likely was a sequencing error L08429 (released 1993-08-24)
The 636C>A substitution of this sequence is usually not present in RHD and likely was a sequencing artefact X63094 (submitted 1991-11-04, released 1993-04-21)
The M218I substitution is usually not found in RHD and likely represents a sequencing artefact X63097 (submitted 1991-11-04, released 1993-04-21)
CDe haplotype KY617091 (submitted 2017-02-13, released 2017-07-12)
CDe haplotype; IVS substitutions 149-29G>C and 336-56 delATGA KY617090 (submitted 2017-02-13, released 2017-07-12)

ISBT group

standard RHD

Phenotype characterization and grouping

D positive (apparently normal)


No data


African American: SWiTCH trial Chou ST et. al. Blood Adv. 2017 Aug 3;1(18):1414-1422. doi: 10.1182/bloodadvances.2017007898. Frequency 1:0,565

Additional comments

Observed in haplotypes CDe, cDE, cDe and CDE

Last update: 2018-02-18 (yyyy-MM-dd)