weak D type 122

Structure

RHD(R70W)

Key changes from standard allele

208C>T (R70W)

ISBT allele designation

RHD* 01W.122
RHD*weak D type 122

Nucleotide changes relative to "standard RHD"

c.208 C>T

Amino acid changes relative to standard protein

Arg to Trp at codon 70

R70W

Haplotype (typical)

not reported

Allele cluster

Eurasian D cluster

Descriptions

First submission to GenBank: 2011 JF816274 (submitted 2011-04-18, released 2011-10-09)

Other relevant descriptions:
Fichou Y et. al. Transfusion. 2012 Apr;52(4):759-64. (submitted 2011-04-19, released 2011-09-29)
LC075268 (submitted 2015-08-17, released 2015-09-08)

ISBT group

weak D

Phenotype characterization and grouping

weakened D expression; weak D type

Serology

Discrepant results with different anti-D Fichou Y et. al. Transfusion. 2012 Apr;52(4):759-64.
weak D LC075268

Observations

France (general): Fichou Y et. al. Transfusion. 2012 Apr;52(4):759-64.
India (general): Fichou Y et. al. Transfusion. 2018 Feb 25. doi: 10.1111/trf.14552.
Japan (general): LC075268

Related Alleles

weak D type 45.2 [RHD(R70W,A273V,A399T)]

Additional comments

Last update: 2018-05-23 (yyyy-MM-dd)